Poliomyelitis

pah therapy :: Article Creator MSD Leaps On FDA Approval Of PAH Drug Sotatercept News MSD MSD's sotatercept has become the first FDA-approved therapy for pulmonary arterial hypertension (PAH) that addresses the underlying mechanism behind the disease, rather than its symptoms. The first-in-class activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein, given the trade name Winrevair, has been cleared to improve exercise capacity, improve lung function, and reduce the risk of worsening clinical events in adults with PAH after a priority review. PAH is a life-threatening disease, caused by the narrowing of blood vessels in the lungs, which is currently treated mainly with drugs that dilate the blood vessels, like endothelin antagonists and prostacyclin analogues, as well as phosphodiesterase inhibitors to increase blood flow through the lungs. Winrevair is thought to work by blocking abnormal signalling between cells in the...

collapsed lung causes :: Article Creator What Does It Mean When Your Left Lung Hurts? The lungs have few pain receptors, so pain in the lungs usually starts elsewhere in the body. Possible causes of left-side lung or chest pain when breathing in include costochondritis and pneumothorax. However, some lung-related conditions can result in pain in the left lung. The chest contains several vital organs, including the heart and lungs. Because of this, it is understandable why someone experiencing pain in this area may worry about what is causing it. This article examines some potential causes of lung pain and what people can do if they experience this symptom. The following include some of the more common causes of lung pain, including left lung pain: Asthma Asthma is a condition that causes airway inflammation and lung irritability, which makes people more prone to wheezing and shortness of breath. Chronic coughing and wh...

bp high treatment at home :: Article Creator A Better Way To Make High Blood Pressure Treatment Decisions New research suggests that when deciding whether to start medication for high blood pressure, it's important to consider not just the short-term, but also the long-term risk of developing cardiovascular disease (CVD). This study, published in Hypertension, compares two tools used to calculate these risks: the American Heart Association's PREVENT calculator and the Pooled Cohort Equations (PCE). "Many people may not have a heart attack or stroke, or develop heart failure in the next few years, yet they may benefit from lowering their blood pressure to protect them against these conditions later in life," said Paul Muntner, Ph.D., the study's lead author and a visiting professor at the University of Alabama at Birmingham. He suggests that experts should consider both near-term and lifetime risks for heart disease wh...

pulmonary hypertension and portal hypertension :: Article Creator Active Plant Substance Reduces Pulmonary Hypertension image:  Daniela Wenzel, Michaela Matthey and Alexander Seidinger (from left) tested the effect of the substance FR on pulmonary hypertension.   view more  Credit: © RUB, Marquard What causes pulmonary hypertension The blood pressure inside the lungs is typically much lower than in the rest of the body. Pulmonary hypertension occurs when the blood vessels within the lungs contract and the smooth muscle layer surrounding these vessels thickens. The disease puts constant stress on the right heart, as it needs considerably more strength to pump the blood through the lungs. As a result, the heart becomes enlarged and may eventually fail due to overload. "The causes of pulmonary hypertension are often obscure," points out Alexander Seidinger. As part of his doctoral thesis, he focused on finding new treatment opt...

acute pulmonary edema heart failure :: Article Creator Recognizing Pulmonary Edema: Key Warning Signs To Watch For MadameNoire Featured Video Pulmonary edema is a critical condition where fluid accumulates in the lungs, causing leakage from blood vessels into air sacs normally filled with air for oxygen exchange. This accumulation impedes breathing and reduces oxygen transfer into the bloodstream.  Michael Arterburn, who goes by @killer_bee_tactical on Instagram, highlighted the dangers of pulmonary edema in a post on May 10. He referenced the tragic case of Ray Johnson, a 64-year-old from Michigan who allegedly developed the condition and died in February 2022 after snorkeling in Maui. Although officially ruled a drowning, Johnson's lawyers argue he succumbed to rapid onset pulmonary edema—a severe variant where the lungs fill rapidly with fluid, compromising oxygen delivery and leading to hypoxia, Fox News rep...

vsd with severe pah :: Article Creator Analysis Supports Initial Combination Therapy For Patients With PAH, Comorbidities Patients with pulmonary arterial hypertension and cardiopulmonary comorbidities are typically started on monotherapy, but new data suggest some patients would do well with initial combination therapy. Patients with pulmonary arterial hypertension (PAH) and one or two cardiac comorbidities experience a similar benefit from initial combination therapy with macitentan (Opsumit) and tadalafil (Cialis) as patients without comorbidities, according to a new analysis. The findings are important because they call into question existing guidelines for patients with cardiopulmonary comorbidities, which suggest beginning with initial monotherapy with either an endothelin receptor antagonist (ERA; e.G. Macitentan) or phosphodiesterase 5 inhibitor (PDE5i; e.G. Tadalafil) and then escalating as appropriate based on individual patient response...

heart failure in young adults :: Article Creator Homeless La Crosse Veteran Diagnosed With Heart Failure Finds Peace In Final Weeks Brad Schwaegerl stood outside his tent, taking deep breaths of the humid summer air along the La Crosse marshland walking trail. He has been confined to his tent more often lately, but as soon as he steps out, favors from neighbors start falling his way. A long-time friend brought four couch cushions to pad his bed and another passerby put a cup of ice water in Schwaegerl's hand before continuing down the path. Schwaegerl looked slightly surprised, but joyful for the help. He has received extra help the past few weeks, cashing in goodwill he's banked over years among the unhoused community. Recently, Schwaegerl received news he was not ready to hear: he's dying. The 56-year-old veteran was diagnosed with heart failure because his heart is not circulating blood efficiently enough...