Poliomyelitis

Companies GSK plc Follow Moderna Inc Follow Pfizer Inc Follow Haleon Plc Follow LONDON, April 26 (Reuters) - GSK (GSK.L) began 2023 with a quarterly performance that beat analyst expectations and extended a series of positive results following strong sales of its roster of vaccines as well as HIV and respiratory medicines. It reaffirmed its guidance for 2023, saying it expected adjusted operating profit growth to be higher in the second half, but lower in the first half of the year when expected drug launches will increase costs. The British drugmaker carved out its consumer health business Haleon (HLN.L) last year and has in recent quarters begun to reverse years of underperformance relative to its peers and from largely missing out on the market for COVID-19 vaccines. Even after stripping out one-time contributions, the underlying revenue and earnings beat are a respectable 3% and 4% respectively, Citi analyst Andrew Baum wrote in a note. He added there was little material risk to GS...

Department of Health | News | Recognizing National Infant Immunization Week, NJ Health Department Raises Awareness About Importance of Childhood Vaccination Home 2023 Recognizing National Infant Immunization Week, NJ Health Department Raises Awareness About Importance of Childhood Vaccination Recognizing National Infant Immunization Week, NJ Health Department Raises Awareness About Importance of Childhood Vaccination Last Reviewed: 4/24/2023 ...

Abstract Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are desperately needed, as are research tools to aid in their discovery and development. Vancomycin is a glycopeptide antibiotic that is widely used for the treatment of Gram-positive infections, such as life-threatening systemic diseases caused by methicillin-resistant Staphylococcus aureus (MRSA). Here we demonstrate that modification of vancomycin by introduction of an azide substituent provides a versatile intermediate that can undergo copper-catalysed azide−alkyne cycloaddition (CuAAC) reaction with various alkynes to readily prepare vancomycin fluorescent probes. We describe the facile synthesis of three probes that retain similar antibacterial profiles to the parent vancomycin antibiotic. We demonstrate the versatility of these probes for the detection and visualisation of Gram-positive bacteria by a range of methods, including plate reader quantification, flow cytometry analysis,...

The dreaded tick-borne encephalitis (TBE) virus infects different types of brain cells in different parts of the brain, depending on whether the affected person's immune system is activated or not. This is shown in a new study at Umeå University, Sweden. "This increased understanding of how the virus behaves in the brain and how it activates the immune system is a crucial step in the development of effective treatments and preventive measures against this difficult disease," says Anna Överby, professor at Umeå University and leader of the research group behind the current study. What the Umeå researchers have mapped is how the TBE virus infects the brain to cause encephalitis. The researchers developed a method to three-dimensionally determine the location of viruses in the brain of mice and determine which specific parts of the brain have been infected with TBE virus. The method is based on information from image analyses that were combined with studies of gene expre...

(Precision Vaccinations) A team of researchers has tracked the arrival and progression of H5N1 bird flu (Avian influenza) outbreaks in Canada, Mexico, and the United States. Led by the University of Maryland (UMD) researchers, this team found an unusual change from seasonal highly pathogenic avian influenza (HAPI) to year-round infections and a far more significant impact on birds, mammals, and people. "We've been dealing with low pathogenic avian influenza for decades in the poultry industry, but this is different," commented Jennifer Mullinax, assistant professor in the UMD Department of Environmental Science and Technology and a co-author of the study, in a press release on April 19, 2023. "This high pathogenic virus is wiping out everything in numbers that we've never seen before," she added. "This paper illustrates how unprecedented it is and describes what we think is c...

[unable to retrieve full-text content] Hand Fungus or Eczema? Here Is How to Tell    Healthgrades

Toenail fungus is an unsightly problem. Fortunately, you have options for getting rid of onychomadesis. Today, many people take toenail fungus supplements to eliminate toenail fungus. Toenail fungus supplements support your immune system and kill fungi, helping your body naturally get rid of fungus. We tested, rated, and ranked the world's most popular toenail fungus supplements. Here's what we found. Our Rankings of the Best Fungus Support Supplements Every toenail fungus supplement claims to get rid of fungus. Some work, while others don't. After hundreds of hours of research and deliberation among our editorial team, here's how we ranked the world's most popular toenail fungus supplements. Kerassentials Kerassentials is a plant-based blend of oils and minerals to nourish your skin and nails from the outside in. Just apply the oil to your toenail fungus daily to boost your natural defenses against nail fungus, fighting your current infection and pr...