The changing face of pulmonary hypertension diagnosis: a historical perspective on the influence of diagnostics and biomarkers



heritable pulmonary arterial hypertension :: Article Creator

What Is Pulmonary Hypertension?

SPEAKER

If you have pulmonary hypertension, it means you have high blood pressure in your pulmonary arteries, the blood vessels that carry blood from the right side of your heart through your lungs.

PH happens when tiny arteries in your lungs get narrow.

This higher pressure makes your heart work harder to pump Over time, your heart gets weak and starts to fail.

You may not have any symptoms at first, but it's really important to get treated quickly. So tell your doctor right away if you're short of breath, tired, dizzy, or have fainting spells, or if you have chest pain, fast heartbeat, or swelling in your feet or legs.

There is no cure yet, but there are things that can and using oxygen. PH is different for everybody, so talk to your doctor to find the best treatment for you.

Remember, catch it early, and treat it quickly to slow it down and help you feel better. [MUSIC PLAYING]


Integrin α5β1 Is Target For Pulmonary Arterial Hypertension

Cardiovascular

Researchers from Morphic Therapeutic Inc. And affiliated organizations published data from a study that aimed to assess the potential of using arginylglycylaspartic acid (RGD) integrins for the treatment of cardiovascular diseases, such as pulmonary arterial hypertension (PAH).

BioWorld Science Cardiovascular

The Sheffield Teaching Hospitals Observational Study Of Patients With Pulmonary Hypertension, Cardiovascular And Other Respiratory Diseases (STH-ObS)

The objective of this study is to collect detailed longitudinal clinical phenotypic information linked to bio-samples from patients with pulmonary hypertension, cardiovascular disease, and other lung / respiratory diseases including COVID-19 and compare with appropriate control groups including healthy volunteers.

We aim to better understand the effect of current treatments and monitoring treatment response and better understand the molecular mechanisms of disease to increase our understanding of the causes, presentations and management of these conditions. This cohort is important part of a national projects examining the genetic and molecular architecture of pulmonary hypertension with major awards from the Medical Research Council and British Heart Foundation.

During the 2020 coronavirus pandemic we amended our protocol to allow the collection of samples and data from patients with coronavirus, and healthcare workers to enable us to conduct research into any long-term effects on lung, pulmonary and cardiovascular health.

We have worked with a number of academic and industry collaborators and are registered with the UK Tissue Directory and Coordination Centre, and have contributed samples to the NIHR BRIDGE study and National Cohort of Idiopathic and Heritable Pulmonary Arterial Hypertension.

Investigation into OPG and related biomarkers in incident cases of pulmonary hypertension

We have discovered that the protein osteoprotegerin (OPG) is involved in the disease process and is easily measurable in patient blood samples. The aim of this study is measure OPG in the blood of patients with Pulmonary Hypertension and related conditions to determine whether it can be used as a biomarker to assess disease progression.

Identifying proteomic biomarkers to detect pulmonary arterial hypertension in patients with systemic sclerosis

We are investigating a proteomic approach (MYRIAD RBM) to discover a protein biomarkers signature using machine learning approaches to help screen for the development of pulmonary arterial hypertension in an at-risk population of patients with systemic sclerosis.

Identifying miRNA signatures for Pulmonary Hypertension

We are investigating the use of miRNA's found in plasma to discover a disease signature using machine learning approaches to help screen for the development of pulmonary hypertension.

Integration of real-world mobile activity and heart rate/rhythm data to detect cardiopulmonary disease and identify 'signatures' of treatment response and 1-year risk scores in PAH.

Working with Euan Ashley and Steve Hershman (Stanford) we are linking data captured by iOS Health and the MyHeart Counts App to address a number of aims and projects.

1. Improve screening to identifying patients at risk of pulmonary hypertension.

2. Assess treatment response and disease progression to test and compare the prognostic accuracy of real-world activity/cardiac function data from MyHeart Counts with standard in-hospital clinical assessments, 1-year risk assessment, biomarkers and patient outcome.

3. Capture real-world activity data from family members of patients with heritable PAH (UK Cohort Study) to identify 'signals' of early disease development.

4. Capture real-world activity of patients and healthcare workers at risk or, or recovering from COVID-19.

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  • Chen K-H, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K , Theilmann AL et al (2018) Epigenetic Dysregulation of the Drp1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.. Circulation, 138(3), 287-304. View this article in WRRO
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  • hodes CJ, Wharton J, Ghataorhe P, Watson G, Girerd B, Howard LS, Gibbs JSR, Condliffe R, Elliot CA, Kiely DG , Simonneau G et al (2017) Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study. The Lancet Respiratory Medicine, 5(9), 717-726. View this article in WRRO
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    • Contact

    Further details about The Sheffield Teaching Hospitals Observational Study of Patients with Pulmonary Hypertension, Cardiovascular and other Respiratory Diseases (STH-ObS) can be obtained from Dr Roger Thompson or Dr Lisa Watson (lisa.Watson24@nhs.Net), who can supply information about access to samples.





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