Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology
How High Blood Pressure Can Raise The Risk Of Uterine Fibroids
Medications that help control high blood pressure may offer a new strategy for the prevention of uterine fibroids.
Research published in the journal JAMA Network Open reports that women in midlife with untreated or new onset hypertension have an increased risk of fibroids while those who are on antihypertensive treatments for blood pressure have a lower risk.
"Investigation into mechanisms and health implications is warranted; if the associations are causal, antihypertensive medication use where indicated may present an opportunity to prevent clinically apparent fibroid development at this high-risk life stage," the study authors wrote.
Nearly 120 million adults in the United States have high blood pressure, also called hypertension. About 44% of them are women.
High blood pressure can create health issues for the heart as well as the eyes, kidneys, and brain.
A growing body of research also suggests an association between high blood pressure and uterine fibroids, a type of muscular tumor that grows in the walls of the uterus.
"Several prospective studies have now shown that elevated blood pressure associates with the presence of uterine fibroids. While this does not prove causation per se, and residual confounding is always possible, this has been a robust association across multiple patient cohorts spanning women of different age ranges. One of the most interesting new findings in this study is that treatment with antihypertensive medications lowered the risk of a self-reported diagnosis of uterine fibroids," said Dr Vivek Bhalla, an associate professor of medicine specializing in hypertension at Stanford University in California who was not involved in the study.
"Based on both clinical and basic research findings, there has been a suggestion that causes of elevated blood pressure (eg activation of the renin-angiotensin system) may contribute to uterine smooth muscle cell injury and, therefore, the development of fibroids," Bhalla told Medical News Today. "Elevated blood pressure itself, either via atherosclerosis or shear stress or both, may also contribute. On the other hand, the presence of uterine fibroids may also raise blood pressure. Therefore, the relationship may be bidirectional but prospective studies suggest that hypertension may at least cause fibroids."
Between 20% and 80% of women develop uterine fibroids by the time they are 50. They are most common in women in their 40s and early 50s.
Research suggests there are some similarities between fibroids and hypertension. Both are common, both are associated with morbidity, both involve changes to smooth muscle cells, and both are more common in people of African descent.
Fibroids don't always cause symptoms, but if symptoms do occur they can be challenging and include pain, heavy menstrual bleeding, frequent urination, and pressure in the rectum.
Research suggests that hypertension is a consistently identified risk factor for fibroids.
"Fibroids are one aspect of a list of different reasons as to why being aware of your blood pressure status, as well as treating it, is going to be critically important. We're starting to understand that the blood pressure in different organ systems is as important as your heart," Dr. Nicole Weinberg, a cardiologist at Providence Saint John's Health Center in California who was not involved in the study, told Medical News Today.
The new research suggests that some blood pressure medications may have an impact in preventing fibroids from developing.
"Antihypertensive medications can lower blood pressure and possibly the risk of atherosclerosis and/or smooth muscle injury of the arteries that provide blood flow to the uterus. There are also classes of antihypertensive medications, ie inhibitors of the renin-angiotensin system, that may have a direct effect. In this study, these inhibitors were associated with the largest risk reduction," Bhalla said.
However, the new research does not determine how exactly blood pressure medications might work to prevent fibroids from occurring.
Some experts argue more research is needed before these findings can have clinical relevance.
"The study does not really describe or postulate how anti-hypertensive medications might prevent the development of uterine fibroids. The mechanism of action of all of these anti-hypertensives are different. They just note that there is a correlation or association between being treated for hypertension and incidence of uterine fibroids," said Dr. G. Thomas Ruiz, the lead OB/GYN at MemorialCare Orange Coast Medical Center in California who was not involved in the study.
"This is the type of study that really needs to focus on the mechanism of action on how an anti-hypertension could potentially prevent the development of fibroids and then produce a dose which minimizes systemic side effects while achieving the preventative goal. I'm not sure this is realistic," he told Medical News Today.
Dr. Parveen Garg, a cardiologist at Keck Medicine of USC in California who was not involved in the study, says while more research is needed, this study is an important reminder that hypertension should be taken seriously.
"We already know that high blood pressure, if it's untreated, leads to pretty disastrous consequences all throughout the body. But this basically just reinforces that we need to take high blood pressure seriously and we need to treat it when we recognize it," he told Medical News Today.
"In general, we know that hypertension causes much more serious comorbidities. Heart failure, stroke, heart disease, kidney failure. If left untreated, it leads to some really serious comorbidities that can be life threatening," Garg added.
Regardless of whether or not medications for high blood pressure help prevent fibroids, experts say it is essential the people with hypertension take steps to manage their condition.
"With any patient with hypertension, especially for patients at high cardiovascular risk, vigilant attention to diet and lifestyle changes and as needed for persistently elevated blood pressure, antihypertensive medications, lower overall cardiovascular risk," Bhalla said. "Whether treatment with medication lowers the risk of the development of fibroids will require additional studies. This paper is an intriguing step in that direction."
Top 6 Best Beet Supplement For High Blood Pressure In 2024
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Millions of people worldwide are dealing with the health issue of high blood pressure. Several medications are available to help manage blood pressure, however, some prefer natural methods. Beetroot supplements have gained popularity over the last few years as a natural alternative.
Beets are a rich source of nitrates, which can help dilate blood vessels and improve blood flow. This, in turn, can help lower blood pressure levels. Several studies have shown that beet supplements can be an effective way to manage hypertension.
When it comes to choosing the best beet supplement for high blood pressure, there are a few critical factors to consider. Firstly, the supplement should contain a high concentration of nitrates to be effective. Secondly, it should be free from additives and fillers that can negate the supplement's benefits. Lastly, the supplement should be easy to consume and digest.
We spent hours researching and testing various beet supplements to identify the ones that are best suited for managing high blood pressure. Our top picks are based on the concentration of nitrates, purity, and ease of use. In the following sections, we will discuss each of our top picks in detail, along with their pros and cons.
Best Beet Supplements for High Blood PressureWe understand the importance of maintaining a healthy blood pressure level, and we know that it can be challenging to achieve this through diet alone. That's why we've researched and tested various beet supplements that claim to help regulate blood pressure. After careful consideration, we've compiled a list of the best beet supplements for high blood pressure. Our recommendations are based on effectiveness, quality, and customer reviews. Check out our top picks below.
1. Nautical Elements Beet Root CapsulesIf you're looking for a natural supplement to help with high blood pressure, digestive issues, and athletic performance, Nautical Elements Beet Root Capsules are worth considering.
Pros
Cons
We tried Nautical Elements Beet Root Capsules for a month and noticed a slight improvement in our blood pressure levels. The capsules are easy to swallow, and we didn't experience any aftertaste or unpleasant side effects. The fact that they're made in the USA and under GMP standards is reassuring and adds to our confidence in the quality of the product.
One thing to keep in mind is that not everyone may see the same results, and some people may experience mild side effects like stomach upset or diarrhea. However, we think it's worth giving Nautical Elements Beet Root Capsules a try if you're looking for a natural and safe way to support your blood pressure, athletic performance, and overall health.
In summary, if you're looking for a natural supplement to help with high blood pressure, digestive issues, and athletic performance, Nautical Elements Beet Root Capsules are worth considering. With their potent beet root powder and pure ingredients, they offer a safe and effective way to support your body's daily activities.
2. HumanN SuperBeets Heart ChewsWe highly recommend the humanN SuperBeets Heart Chews for anyone looking for a natural way to support their blood pressure and energy levels.
Pros
Cons
We were impressed with the unique combination of clinically studied polyphenols from French Grape Seed Extract and non-GMO beet root powder in each chew. This powerful blend may support Nitric Oxide production, which can help promote healthy circulation and blood pressure support. Plus, the Grape Seed Extract may also help prevent the destruction of Nitric Oxide by free radicals.
We also appreciated the convenience of the individually wrapped chews, making them perfect for on-the-go use. The natural pomegranate berry flavor was a nice touch, and we were happy to see that there were no artificial sweeteners in the ingredients.
While the price point may be a bit steep for some, we believe that the quality of the ingredients justifies the cost. However, it may take some time to see noticeable results, so it's important to be patient and consistent with use.
Overall, we were impressed with the humanN SuperBeets Heart Chews and would recommend them to anyone looking for a natural way to support their blood pressure and energy levels.
3. Earth Harmony Naturals Organic Beet Root CapsulesWe highly recommend Earth Harmony Naturals Organic Beet Root Capsules for those looking to improve their heart and circulatory health.
Pros
Cons
We have personally tried Earth Harmony Naturals Organic Beet Root Capsules and have noticed improved circulation and energy levels. The supplement is also vegan-friendly and free of gluten, soy, dairy, GMOs, artificial flavors, and toxic fillers.
In addition to its cardiovascular and circulatory benefits, this supplement can also help increase blood flow and boost performance during workouts. We appreciate the simplicity of the ingredient list, which consists of only organic beet root powder and juice blend.
Overall, Earth Harmony Naturals Organic Beet Root Capsules are a great choice for those looking to support their heart and circulatory health, boost energy levels, and strengthen their immune system.
4. Clinical Daily Beet Root Powder TabletsWe highly recommend Clinical Daily Beet Root Powder Tablets for those looking for a natural and effective way to support their blood pressure and overall health.
Pros
Cons
We have been using Clinical Daily Beet Root Powder Tablets for a few weeks now and have noticed a significant improvement in our blood pressure and overall energy levels. The tablets are easy to take and the high absorption rate ensures that we are getting the maximum benefits from the beets. We appreciate that the product is made in the USA and is GMP certified for safety and quality.
The natural fiber, vitamins, and minerals in the beets also provide additional health benefits, such as supporting immune response and reducing inflammation. We like that the tablets are vegan-friendly and free from GMOs. The child-proof lid and BPA-free bottle also provide peace of mind.
Overall, we highly recommend Clinical Daily Beet Root Powder Tablets for those looking for a natural and effective way to support their blood pressure and overall health.
5. Force Factor Total Beets Blood Pressure Support SupplementsWe highly recommend Force Factor Total Beets Blood Pressure Support Supplements for those looking to improve their cardiovascular health.
Pros
Cons
We have been using Force Factor Total Beets Blood Pressure Support Supplements for a few weeks now and have noticed a significant improvement in our blood pressure levels. The chews are easy to take and have a great taste, making it easy to incorporate into our daily routine. We appreciate that the supplement contains MegaNatural-BP, a clinically proven ingredient that supports heart health. Additionally, the product provides clear, heart-healthy energy without any artificial colors, sweeteners, or stimulants.
One downside of the product is that it contains artificial flavors, which some people may want to avoid. Additionally, the product is relatively expensive compared to other beet supplements on the market. However, we believe that the benefits of the supplement outweigh the cost.
Overall, we highly recommend Force Factor Total Beets Blood Pressure Support Supplements to anyone looking to improve their cardiovascular health. The product is convenient, delicious, and provides a simple way to enjoy the benefits of beets.
6. VITAMIZED Potent Beetroot Gummies 1000mg – Nitric Oxide SupplementIf you're looking for a tasty and practical way to regulate your blood pressure and improve your overall heart health, VITAMIZED Potent Beetroot Gummies might be the right choice for you.
Pros
Cons
We have been using VITAMIZED Potent Beetroot Gummies for a few weeks now, and we have noticed a difference in our energy levels and overall wellness. The gummies are easy to take, and the pomegranate flavor makes them a tasty treat. We appreciate that the supplement is enriched with vitamins, including Vitamin C for antioxidants and Vitamin B12 for energy boost. We also like that the product is vegan, gluten-free, and GMO-free, making it suitable for a wide range of dietary needs.
One downside of the product is that the gummies are a bit hard, so you might need to suck on them instead of chewing. They are also sticky to teeth, which might be uncomfortable for some people. Additionally, we noticed that the product is produced in Asia, which might be a concern for those who prefer products made in the USA.
Overall, we would recommend VITAMIZED Potent Beetroot Gummies to anyone looking for an easy and tasty way to regulate their blood pressure and improve their overall heart health. The product is packed with nitriles that our body turns into Nitric Oxide, helping with blood circulation and balanced pressure levels. Plus, the added vitamins make it a great supplement for overall wellness.
Buying GuideWhen choosing the best beet supplement for high blood pressure, there are several factors to consider. Here are some key features to look for:
Nitrate ContentThe nitrate content of the supplement is an important factor to consider. Nitrate is the key component of beets that helps to lower blood pressure. Look for a supplement that has a high nitrate content, ideally around 500mg per serving.
PurityMake sure the supplement you choose is pure and free from contaminants. Look for products that are third-party tested and certified to ensure their quality.
FormBeet supplements come in several forms, including capsules, powders, and liquids. Choose the form that is most convenient for you and fits your lifestyle.
DosageCheck the dosage instructions carefully to ensure you are taking the correct amount of the supplement. Some supplements may require multiple servings per day, while others may only require one.
PriceBeet supplements can vary in price, so it's important to consider your budget when choosing a product. However, it's important to remember that the cheapest option may not always be the best quality.
By considering these factors, you can choose the best beet supplement for your needs and help to manage your high blood pressure.
Frequently Asked Questions What are the benefits of taking beet supplements?Beet supplements are known to improve blood flow, boost exercise performance, and support brain health. They are also rich in antioxidants, which can help protect against cellular damage caused by free radicals.
How do beet supplements affect blood pressure?Beet supplements contain nitrates, which can help relax blood vessels and improve blood flow. This can lead to a reduction in blood pressure, especially in individuals with high blood pressure.
Are there any side effects of taking beet supplements?While beet supplements are generally safe for most people, they may cause some side effects such as gastrointestinal discomfort, nausea, and headaches. These side effects are usually mild and go away on their own.
What is the recommended dosage for beet supplements?The recommended dosage for beet supplements varies depending on the product. However, most supplements recommend taking 500-1000mg per day, divided into two doses.
Which brands of beet supplements are highly rated?Some highly rated brands of beet supplements include PureBeets, Nature's Way Beet Root Powder, and HumanN SuperBeets. However, it's important to do your own research and choose a brand that fits your individual needs.
Can beet supplements be taken with other medications?While beet supplements are generally safe, it's always best to consult with your healthcare provider before taking them with other medications. Beet supplements may interact with certain medications, such as blood thinners, and can cause adverse effects.
Treating High Blood Pressure May Help Reduce The Risk Of Developing Fibroids
Hypertension medications are associated with a lower risk of uterine fibroids in people with high blood pressure.
A new study, published in JAMA Network Open Tuesday, found that women who were newly diagnosed with hypertension in their 40s and 50s had a higher risk of uterine fibroids, which are benign tumors in the uterus.
The risk of being diagnosed with a fibroid decreases with hypertension treatment, such as ACE inhibitors.
The report adds to growing evidence suggesting there's a link between cardiovascular risk factors, like cholesterol levels, and uterine fibroids.
But that relationship isn't well understood.
"More research is definitely required in order to better understand the link between high blood pressure and fibroid development and thus put this into clinical practice," Supreeti Behuria, MD, a cardiologist at Staten Island University Hospital, told Healthline.
Behuria is not connected to the study.
The study evaluated the health data of 2,570 participants, sourced from the Study of Women's Health Across the Nation, between the ages of 42 and 52 who did not have a history of uterine fibroids.
The participants were tracked from their enrollment in the study, which occurred between 1996 and 1997, all the way through 13 semi-annual follow-up visits, which were held between 1998 and 2013.
The participants had their blood pressure, biomarkers (which included (cholesterol, triglycerides, and C-reactive protein), and physical measurements recorded at each medical visit. Additionally, they were asked whether or not they used medications to treat hypertension.
The research team also looked at fibroid diagnoses.
Over the course of the study, 20% (526 women) reported a new fibroid diagnosis.
The researchers found that, compared to people who did not have high blood pressure, those with untreated hypertension had a 19% greater risk of developing fibroids and those with treated hypertension had a 20% lower risk of getting a fibroid.
Of the group who had hypertension, those who sought treatment had a 37% lower risk of being diagnosed with fibroids compared to those who did not pursue treatment.
Those who took ACE inhibitors had a 48% lower risk.
In addition, compared to people who never had hypertension, those with new-onset hypertension had a 45% greater risk of being diagnosed with a fibroid.
According to the researchers, the findings highlight the relationship between cardiovascular health and the development of fibroids.
G. Thomas Ruiz, MD, a board-certified OB/GYN and lead OB/GYN at MemorialCare Orange Coast Medical Center in Fountain Valley, CA, says it's important to understand that the report doesn't describe how anti-hypertension medications might prevent uterine fibroids. Ruiz was not involved in the study.
"They just note that there is a correlation or association between being treated for hypertension incidence of uterine fibroids," he said.
Prior research has similarly found that ACE inhibitors — a type of drug that relaxes the veins to lower blood pressure — were associated with 32% lower odds of being diagnosed with a fibroid.
Preliminary evidence suggests ACE inhibitors have this effect because of their involvement with the renin-angiotensin-aldosterone pathway, which is the pathway in the kidneys by which ACE inhibitors work to control blood pressure.
That said, it's important to consider that hypertension medications do have side effects.
"The study does discuss the use of anti-hypertensive in preventing the development of uterine fibroids, however, anti-hypertensives do have side effects, such as, low blood pressure, decreased heart rate," Ruiz said.
The researchers say the findings may inform future strategies to prevent uterine fibroids.
"Fibroid prevention is of course, extremely important, as the presence of fibroids can negatively impact a person's quality of life, with the pain that comes from fibroids, and the bleeding and discomfort women experience," said Behuria.
Additionally, more research is needed to better understand why blood pressure medication has this effect.
Hypertension medications are associated with a lower risk of uterine fibroids in people with high blood pressure. The report adds to growing evidence suggesting there's a link between cardiovascular risk factors, like cholesterol levels, and uterine fibroids.
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