Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on ...
Hypertension News
Nov. 13, 2023 — An intensive three-year intervention to lower the top blood pressure number to less than 120 mm Hg was more effective at preventing death, heart attack, stroke and other cardiovascular events in ...
Nov. 13, 2023 — Nearly everyone can lower their blood pressure, even people currently on blood pressure-reducing drugs, by lowering their sodium intake, reports a new study. It found 70-75% of all people, ...
Nov. 2, 2023 — A study found that participants in a mindfulness-based blood pressure reduction program improved health behaviors that lower blood pressure. When people who had elevated blood pressure participated ...
Oct. 24, 2023 — Newly published research proves that it's possible to treat high blood pressure by using specially engineered Lactobacillus paracasei to produce a protein called ACE2 in the gut, reducing gut ...
Oct. 19, 2023 — New findings point to 2 additional probiotics as potential treatments for high blood ...
Oct. 16, 2023 — The link between high blood pressure and a range of health problems is well known, and researchers have now found that fluctuating blood pressure can be just as risky and a potential precursor to ...
Oct. 2, 2023 — Getting enough sleep has never been more difficult in today's fast-paced environment. Yet new research highlights why getting a good night's sleep is critical to staying healthy. Their ...
Sep. 27, 2023 — An estimated 80 percent of older adults in the U.S. Have high blood pressure. Maintaining healthy blood pressure can protect against serious conditions like heart failure, heart attacks, and strokes. ...
Sep. 7, 2023 — An analysis of data from a long-running study of more than 11,000 adults from four diverse communities in the United States has found that adults who had high blood pressure while both seated upright ...
Sep. 7, 2023 — An analysis of electronic health records for more than 60,000 adults in the United States found that systolic, or top-number, blood pressure rose slightly during the winter compared to summer months. ...
Aug. 15, 2023 — Arterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up ...
July 31, 2023 — An analysis of data from seven studies involving more than 19,000 adults in the United States, Korea and Japan found a clear association between increases in systolic (top-number) blood pressure and ...
July 13, 2023 — Expanding home blood pressure monitoring among US adults with hypertension could substantially reduce the burden of cardiovascular disease and save healthcare costs in the long term, according to a ...
June 26, 2023 — Novel research found that apparent resistant hypertension (aRH) prevalence was lower in a real-world sample than previously reported, but still relatively frequent -- affecting nearly 1 in 10 ...
Apr. 7, 2023 — High blood pressure in early adulthood is associated with worse brain health in late life, according to a new study. Men, compared to women, may be more vulnerable to the detrimental effects of high ...
Mar. 23, 2023 — High fitness levels may reduce the risk of death from cardiovascular disease in men with high blood pressure, according to a 29-year ...
Mar. 22, 2023 — If you live near a busy road you might feel like the constant sound of roaring engines, honking horns and wailing sirens makes your blood pressure rise. Now a new study confirms it can do exactly ...
Mar. 14, 2023 — Scientists have found that inhibiting a gene essential to making DNA can significantly reduce the destructive cell proliferation and disease progression in pulmonary ...
Feb. 28, 2023 — A new device that calms overactive kidney nerves with ultrasound consistently lowered blood pressure in patients with uncontrolled hypertension, researchers have ...
Feb. 8, 2023 — In a new analysis involving adolescents living in London, exposure to higher levels of the pollutant nitrogen dioxide was associated with lower systolic blood pressure, while exposure to higher ...
Can CBD Lower Blood Pressure? 5 Options To Try In 2024
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Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:Was this helpful?
Cannabidiol (CBD) is a natural compound that may help reduce some factors in high blood pressure, such as stress, anxiety, and sleep quality issues.
Is CBD legal? Hemp-derived CBD products with less than 0.3% THC are legal federally but still illegal under some state laws. Cannabis-derived CBD products, on the other hand, are illegal federally but legal under some state laws. Check local legislation, especially when traveling. Also, keep in mind that the Food and Drug Administration (FDA) has not approved nonprescription CBD products, which may be inaccurately labeled.
There is some evidence to suggest that CBD may help lower blood pressure.
Doctors may prescribe medications for people with high blood pressure. If someone takes blood pressure medications and uses CBD products, they must inform their doctor.
What does the research say?A 2023 study found that CBD can lower blood pressure in individuals with treated or untreated high blood pressure. The researchers also noted a lack of serious side effects and said the lower blood pressure occurred after 2.5 weeks of CBD administration.
A 2020 study found that CBD may have vasodilatory effects in human and rat arteries. The authors suggest that CBD may improve flow because it widens blood vessels.
Another study found that a single dose of CBD reduced resting blood pressure. However, the authors state this effect nullifies after seven days of treatment. They also say this topic needs further research.
Additionally, a 2021 study assessed the effects of medical cannabis on individuals with high blood pressure. They observed a reduction in blood pressure after three months of use. However, it is important to note that there is no information on whether CBD was a part of this study.
Research from 2023 found that CBD lowers blood pressure in patients with Grade 1 hypertension. While the results are promising, more research is necessary.
A person should not use CBD to replace prescribed high blood pressure medications. They need to consult a doctor if they take this medication and wish to add CBD to their treatment plan.
Learn more about high blood pressure.
CBD can interact with blood pressure medication, changing the blood concentration of these drugs. Taking CBD alongside prescription medication may cause unintentional and dangerous side effects.
People should only take CBD for high blood pressure under the supervision of a healthcare professional.
This full-spectrum CBD oil contains terpenes, flavonoids, and phytocannabinoids that contribute to the "entourage effect," which may provide additional benefits.
The company uses U.S.-grown hemp, and either organic extra virgin olive oil, or fractionated coconut oil and organic flavoring oil.
Charlotte's Web recommends taking two full droppers up to two times per day. The company states that this product may help with a variety of issues, including sleep quality, stress, and exercise-induced inflammation.
Pros & consUse code "healthcbd" for 20% off.
MNT's reviewThese gummies are broad-spectrum, and according to laboratory reports, are free of tetrahydrocannabinol (THC). People will not experience euphoria, or a "high," when using this product.
The company states that these gummies may help with managing stress levels. They also suggest the gummies can provide sleep support and reduce exercise-induced inflammation.
Unlike some gummies, these are U.S. Department of Agriculture (USDA) certified organic, vegan, and gluten-free.
People can take these gummies at any time of the day or night.
Pros & consUse code "healthcbd" for 20% off.
MNT's reviewThis tincture comes in different concentrations and does not contain any alcohol or artificial flavors or colors.
According to Joy Organics, this product may help support physical and mental health, promote a sense of calm, and help in stressful situations.
The company states that this tincture is USDA certified organic. The only ingredients in this product are organic MCT oil, organic hemp extract, organic key lime flavor, and organic stevia.
Pros & consUse code "HEALTHLINE" for 20% off.
MNT's reviewThe brand states that its organic hemp is grown in Colorado and that it manages the entire process from farming to production.
Reviewers note that this product has helped relieve their anxiety and stress symptoms. Some also mentioned improved sleep and less pain.
This product comes in three different sizes: 300, 900, and 1,800 milligrams (mg). A person can buy a pack of multiple bottles for a discounted total price.
Pros & consUse code "HEALTHLINE" for 20% off.
MNT's reviewThe company states that it makes these gummies in the United States. It also says that this product is organic, cruelty-free, vegan, and gluten-free.
Reviewers state that these gummies helped aid relaxation and sleep.
Pros & consThe following table compares the products in this article on CBD content, type, and more.
To find suitable quality CBD for high blood pressure, a person can look for information on:
Learn more about how to shop for CBD.
The Food and Drug Administration (FDA) states that there may be some potential risks when using CBD products. These may include:
A 2017 review found that taking CBD with antihypertensive medications may change the blood concentration of either substance. If an individual uses CBD and blood pressure medications, they need to inform their doctor.
A person can test positive on a drug test for THC, an active ingredient in cannabis.
Learn more about the dosages and side effects of CBD.
CBD and pregnancyThe FDA does not recommend using CBD products during pregnancy or while breastfeeding.
There is not enough research into how CBD may affect a developing fetus. However, some evidence suggests that high doses of CBD in pregnant test animals may affect a male fetus's reproductive system.
More research is necessary to investigate the potential risks of CBD use during pregnancy.
Some other natural ways to lower blood pressure include:
Learn about 15 ways to lower your blood pressure naturally.
There is no particular type of CBD for lowering blood pressure; further research into the effects of CBD is necessary.
However, the blood absorbs some types of CBD faster than others. How people consume CBD has a significant effect on how quickly the body absorbs it:
Learn the difference between CBD oils and tinctures here.
It is important to note that many studies on CBD and blood pressure use high doses of around 600 mg. People should not take these doses without consulting a healthcare professional. Additionally, most research investigates the effect of CBD on mild hypertension. More research is necessary on how it affects other grades of blood pressure.
Some over-the-counter products contain CBD, while some FDA-approved prescription drugs doctors use to treat certain seizures in children also have the substance.
The FDA states that there are risks associated with using CBD, including:
To use CBD safely, start with a small dose. Increase the dose gradually until the desired effect is achieved while remaining alert for signs of side effects.
A person should discuss CBD with their doctor before using it.
Learn more about CBD and seizures.
If people believe they have high blood pressure, they should speak with a doctor. They should not take CBD without checking with a healthcare professional first.
According to the National Heart, Lung, and Blood Institute, doctors may recommend healthy lifestyle changes before prescribing medication.
If these lifestyle changes are ineffective, doctors may recommend the following medications:
People with hypertension do not usually have any symptoms, so those with a higher risk may need regular screening.
Healthcare professionals can suggest a treatment plan to help prevent or treat hypertension. For example, they may prescribe medications to help treat hypertension.
A person should consult a doctor before taking any CBD products, as the interaction between these products and certain medications can cause serious side effects.
People who experience side effects from CBD products should stop using them and seek medical help immediately.
Learn more about blood pressure medications.
Below are some of the most common questions and answers about CBD.
What does CBD do to the brain?CBD stimulates the endocannabinoid system throughout the body and other receptors, such as serotonin receptors. Research has found that CBD enhanced connectivity in parts of the brain in a resting state and supported cognitive activity.
However, according to the FDA, further research into the effects of CBD is necessary, including the effects on the developing brain.
Learn more about serotonin and its function.
CBD stimulates the endocannabinoid system throughout the body and other receptors, such as serotonin receptors. Research has found that CBD enhanced connectivity in parts of the brain in a resting state and supported cognitive activity.
However, according to the FDA, further research into the effects of CBD is necessary, including the effects on the developing brain.
Learn more about serotonin and its function.
Can you get addicted to CBD? What is the difference between CBD and THC?CBD and THC are phytocannabinoids, chemical messengers found naturally in the cannabis plant. One of the most important differences is that CBD is not an intoxicating compound, but THC is, and drug tests can identify it.
Learn whether drug tests can identify CBD.
CBD and THC are phytocannabinoids, chemical messengers found naturally in the cannabis plant. One of the most important differences is that CBD is not an intoxicating compound, but THC is, and drug tests can identify it.
Learn whether drug tests can identify CBD.
Can you take CBD for low blood pressure?As there are many studies indicating that CBD may lower blood pressure, a person with low blood pressure may wish to be cautious. These individuals need to consult a doctor before taking CBD in any form.
As there are many studies indicating that CBD may lower blood pressure, a person with low blood pressure may wish to be cautious. These individuals need to consult a doctor before taking CBD in any form.
How much CBD must you take to lower blood pressure?No research suggests how much CBD a person must take to lower blood pressure. Studies into CBD and blood pressure frequently use high doses of CBD. A person should consult with a healthcare professional before taking such a high dose.
No research suggests how much CBD a person must take to lower blood pressure. Studies into CBD and blood pressure frequently use high doses of CBD. A person should consult with a healthcare professional before taking such a high dose.
Hypertension does not usually cause any symptoms. A person might not know that they have it unless they receive a diagnosis.
There are various medical treatments available. There is also evidence to suggest that products containing CBD may help, but a person should not stop using high blood pressure medication without consulting a doctor first.
A person who uses blood pressure medications should also consult a doctor before using any CBD products.
FDA Approves Potential 'Game Changer' For Pulmonary Arterial Hypertension
Pictured: Merck Research Laboratories in California/iStock, Michael Vi
Merck's $11.5 billion acquisition of Acceleron Pharma paid dividends Tuesday as the FDA approved sotatercept, the cornerstone of the deal, to treat pulmonary arterial hypertension.
The drug, which will carry the brand name Winrevair, is the first FDA-approved activin signaling inhibitor therapy for PAH, according to Merck's announcement. This new therapeutic class improves the balance between pro- and anti-proliferative signaling to regulate vascular cell proliferation, an underlying cause of PAH.
Winrevair is intended to be used alongside existing PAH therapies to increase exercise capacity, lessen the severity of PAH and reduce the risk of disease worsening.
Merck has priced Winrevair at $14,000 per vial before insurance, according to multiple sources.
The drug came into Merck's possession with the 2021 acquisition of Acceleron. "[Winrevair] was the main opportunity that we saw with the Acceleron acquisition," Mahesh Patel, VP of global clinical development at Merck Research Laboratories, told BioSpace. "We have been so fortunate in how well things have gone in the acquisition, executing on the clinical development program and seeing paradigm-changing clinical trial results through it."
In October 2022, Winrevair hit the primary Phase III endpoint, eliciting a statistically significant and clinically meaningful improvement in the 6-minute walk distance test after 24 weeks. The drug also reached statistical significance in secondary endpoints, including time to patient death or the first occurrence of a clinical worsening event.
Patel said that before Winrevair, treatments for PAH had only dilated the arteries, opening blocked or narrowed blood vessels and allowing more oxygen to flow. However, earlier medicines have not addressed the root causes of the disease. Winrevair has the chance to "dramatically change" patients' physical function and quality of life, Patel said.
Tuesday's approval follows that of Johnson & Johnson's Opsynvi, a single-tablet combination of macitentan and tadalafil, which received the FDA's green light on March 22 for adults with PAH.
But Jeremy Feldman, director of the pulmonary hypertension program and medical director for high-risk care at Summit Heath, who was also involved in Winrevair's Phase II and III trials, expressed more excitement about this medicine.
"Without a doubt, sotatercept is a game changer," he told BioSpace. "I think the way that that will impact patients is very different than the availability of a combo tablet that doesn't advance the care of patients. It may advance the convenience of patients a little bit." He added that Winrevair is a particularly effective agent on top of the approved therapies and is particularly well-tolerated in terms of day-to-day side effects. "I think there's a question mark that still has not been fully answered about the long-term safety of the medication, but that's not an unfamiliar space for us to be in with a disease process that has still a very high mortality."
Winrevair's label lists warnings for erythrocytosis, which may increase the risk of thromboembolic events and hyperviscosity syndrome, and severe thrombocytopenia, which may increase the risk of bleeding.
Winrevair and Opsynvi enter a growing PAH market, which Prophecy Market Insights projects will be worth $12.2 billion by 2032. An increasing geriatric population married with global increases in chronic diseases has led to a rise in the need for PAH medicines, according to the report. As of December 2023, approximately 129 drugs were in development for PAH by 110 companies, institutes and universities, Pharmaceutical Technology reported.
Patel said Merck plans to investigate Winrevair for other unmet needs in PAH, including on trial its potential use within one year of diagnosis and a second trial in patients who potentially are at very high risk for progressive morbidity and mortality.
Tim Noyes, CEO of Aerovate Therapeutics, which is also developing a PAH candidate, said this is an "exciting" time to be in the space. For the past 20 years, the "bedrock" of care has been using dilators, or vasodilators, Noyes told BioSpace. While this has made a difference for patients, the underlying problem with PAH is cell proliferation with arteries narrowing from the inside out, he said.
"To get to that next level, to allow patients to really start to have an agent that addresses the underlying cause of their disease, it's anti-proliferative agents and [that's] why there's so much enthusiasm for sotatercept," Noyes said.
Aerovate's candidate, a tyrosine kinase inhibitor, is a dry-powder aerosol version of Novartis' cancer drug Gleevec. Noyes sees the drug as complementary to Winrevair as opposed to being necessarily a competitor. "Each has its . . . Specific benefits to patients, entirely different mechanisms," he explained.
Winrevair will be available to patients at select pharmacies at the end of April, according to Merck's announcement.
"A diagnosis of PAH is a life-changing experience for patients and families due to its chronic, progressive nature. Patients with PAH experience limiting symptoms such as shortness of breath and fatigue," Matt Granato, president and CEO of the Pulmonary Hypertension Association, said in a statement. "We are excited to see industry research leading to a better understanding of PAH and the development of a medicine in a novel treatment pathway that expands options for the patient community."
Tyler Patchen is a staff writer at BioSpace. You can reach him at tyler.Patchen@biospace.Com. Follow him on LinkedIn.
Correction (March 27): This story has been updated from its original version to reflect that Aerovate does believe that its candidate, if approved, could be used in combination with Winrevair. BioSpace regrets the error.
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