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20 Countries With The Highest Heart Disease Deaths Per Capita
In this article, we will be taking a look at the 20 countries with the highest disease deaths per capita. If you do not want to learn about the global heart disease landscape, head straight to the 5 Countries with the Highest Heart Disease Deaths Per Capita.
Heart disease remains a pressing global health concern, with certain countries bearing a disproportionately high burden of mortality attributed to this condition. Understanding the prevalence and distribution of heart disease across different nations is essential for developing targeted interventions and public health strategies aimed at reducing the incidence of this life-threatening condition.
Global and US Heart Disease LandscapeCardiovascular diseases (CVDs) represent a significant global health concern, claiming an estimated 17.9 million lives annually due to heart-related conditions. The burden of heart disease is substantial, affecting individuals worldwide and leading to premature deaths, primarily caused by heart attacks and strokes. In 2020, approximately 19.1 million deaths were attributed to CVD globally, with an age-adjusted death rate of 239.8 per 100,000 population. Ischemic heart disease remains the leading cause of global CVD mortality, with an age-standardized rate of 108.8 per 100,000. The prevalence of stroke in 2020 was reported at 89.1 million people globally.
The United States faces a significant burden of heart disease, with a considerable number of individuals affected by various cardiovascular conditions. Detailed statistics indicate that in the US, approximately 244.1 million people were living with ischemic heart disease in 2020, with higher prevalence rates in males than females. The age-standardized mortality rates for ischemic heart disease were reported at 112.37 per 100,000 population in the same year.
The economic impact of heart disease is substantial globally and in the US. In the US market specifically, the financial implications of managing heart diseases are significant, encompassing costs related to treatment, medication, surgeries, and overall healthcare expenditure. Access to essential technologies and medications for cardiovascular conditions is crucial in the US healthcare system to ensure prompt management of acute events like heart attacks and strokes.
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Revolutionizing Cardiovascular Health: Innovations, Insurance, and EconomicsThe global cardiovascular health landscape is marked by its complexity, with cardiovascular diseases (CVDs) posing a formidable challenge. This necessitates innovative solutions for treatment and management. Both the pharmaceutical and medical device sectors have made significant strides in addressing this challenge. Specifically, pharmaceutical innovations, including gene therapies and RNA-based therapeutics, have reshaped the treatment paradigm. Notable examples include Eliquis (apixaban) by Bristol-Myers Squibb Company (NYSE:BMY), demonstrating superior risk reduction capabilities.
Bristol-Myers Squibb Company (NYSE:BMY) is renowned for its pioneering work in cardiovascular disease (CVD) treatments, focusing on preventing strokes, treating venous thromboembolism, and addressing conditions like Hypertrophic Cardiomyopathy (HCM). Their recent approval of CAMZYOS (mavacamten) as a cardiac myosin inhibitor for obstructive HCM signifies a significant breakthrough, showing efficacy in improving exercise capacity and symptoms. Looking forward, Bristol-Myers Squibb Company (NYSE:BMY) aims to lead in personalized medicine and precision therapies, leveraging innovative research and development. Financially, the company saw a 1% increase in revenues to $11.5 billion in the fourth quarter of 2023, with strong performance from key products like Eliquis and Opdivo. Adjusted EPS decreased by 7% to $1.70 for the same period, and for the full year of 2024, the company expects revenues to increase by low single-digits with adjusted EPS ranging between $7.10-7.40.
Tenaya Therapeutics, Inc. (NASDAQ:TNYA) employs a groundbreaking Gene Therapy platform, utilizing adeno-associated viruses (AAVs) to address root causes of heart diseases such as hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC) with leading treatments like TN-201 and TN-401. Their Cellular Regeneration platform aims to restore heart function post-myocardial infarction by regenerating cardiomyocytes in vivo. Leveraging Precision Medicine with hiPSC-CMs, Tenaya Therapeutics, Inc. (NASDAQ:TNYA) develops tailored treatments for genetic and non-genetic heart diseases. Noteworthy trends include HDAC6 inhibitors for heart failure with preserved ejection fraction (HFpEF) and gene replacement therapies. Financially, Tenaya Therapeutics, Inc. (NASDAQ:TNYA) reported a net loss of $29.9 million for Q4 and $124.1 million for the full-year 2023, emphasizing ongoing investment in genetic medicines for heart disease. Notably, TN-201 for HCM and TN-401 for ARVC are advancing in clinical trials, while TN-301 shows promising data for HFpEF. With $104.6 million in cash and recent financing, Tenaya is well-positioned for future growth.
Medical devices, including implantable cardioverter-defibrillators (ICDs), pacemakers, and stents, play a crucial role in managing cardiovascular conditions, complementing pharmaceutical treatments. Integration of digital health technologies enhances patient care through real-time monitoring and personalized interventions. The global digital health market, valued at $96.5 billion in 2020, is projected to grow at a CAGR of 15.1% from 2021 to 2028.
Amidst these advancements, health insurance trends play a pivotal role in ensuring access to quality cardiovascular care. Insurers are adapting to provide comprehensive coverage encompassing medications, medical devices, diagnostics, and procedures, aligning with the growing demand for accessible healthcare solutions.
20 Countries with the Highest Heart Disease Deaths Per Capita
Samrith Na Lumpoon/Shutterstock.Com
Our MethodologyOur methodology for ranking countries with the highest heart disease deaths per capita involved calculating death rates per capita based on total deaths per capita due to heart diseases. The data we used was heart disease death rates per 100,000 individuals, we initially divided the death rate per 100,000 by 100,000. Then, we multiplied this result by each country's total population and subsequently divided by total population to derive death rates per capita. These figures were then arranged in ascending order to determine the countries with the highest heart disease deaths per capita.
Here is our list of the 20 countries with the highest heart disease deaths per capita.
20. SudanDeath Rate per Capita: 0.002
In Sudan, heart disease presents a significant health challenge, encompassing various conditions such as hypertensive heart disease, rheumatic heart disease, ischemic heart disease, and cardiomyopathy, which collectively account for over 80% of cardiovascular diseases. Hypertension prevalence stands at around 20%, totaling 74,371 deaths. Heart diseases affect individuals across different age groups, including children, with conditions like rheumatic heart disease impacting them.
19. MoroccoDeath Rate per Capita: 0.002
Morocco faces significant challenges with cardiovascular diseases (CVD), particularly heart disease, as it ranks high in CVD-related mortality. The country's healthcare system is strained, with a mortality rate of 38% attributed to CVD. Ischemic heart disease and stroke are the primary causes of death, accounting for 31.0% and 22.5%, respectively. Risk factors contributing to this high mortality rate include tobacco smoking (45-50%), physical inactivity (21.1%), hypertension (25.3%), and depression (5.47%). Middle-aged and older individuals are generally more susceptible to heart diseases like ischemic heart disease and stroke.
18. EgyptDeath Rate per Capita: 0.002
Egypt stands among the countries with the highest disease deaths per capita, with a high prevalence rate of coronary heart disease (CHD) at 5,623.95 per 100,000 individuals and a mortality rate of 359.3 per 100,000. While some individuals recover, there's a notable mortality rate, highlighting the seriousness of the condition. Hospitalized heart failure patients in Egypt range from 52.2 to 62.8 years old, showing its impact across age groups.
17. YemenDeath Rate per Capita: 0.002
Yemen stands among the top countries with high rates of heart diseases. While some individuals recover, many succumb to the disease. Treating heart disease in Yemen poses a significant financial burden on individuals and the healthcare system, highlighting the importance of accessibility to affordable and quality healthcare services.
16. TurkmenistanDeath Rate per Capita: 0.002
In Turkmenistan, coronary heart disease is responsible for 29.02% of total deaths. The country ranks 13th globally for the age-adjusted death rate due to coronary heart disease. Raised blood pressure affects a notable portion of the population, with prevalence rates of 24.1% in women and 26.6% in men. Additionally, tobacco smoking prevalence is high at 12.5%, contributing significantly to cardiovascular disease incidence and mortality rates in Turkmenistan.
15. SyriaDeath Rate per Capita: 0.002
Syria faces a significant burden of coronary heart disease (CHD) mortality, ranking 12th globally for CHD deaths per capita. The prevalence of cardiovascular disease (CVD) is notable, with 4.8% of adults in Aleppo suffering from heart disease and 1.0% from stroke. CVD accounts for 45.0% of total mortality, with 49% of deaths occurring before age 65. The mean age of death due to CVD is approximately 62.6 years. Modern treatments have prevented about one-fourth of total CHD mortality in Syria.
14. MicronesiaDeath Rate per Capita: 0.002
Micronesia faces coronary heart disease issues accounting for nearly 18.8% of total deaths. Raised blood pressure affects over 23% of women and 26% of men, while tobacco smoking prevalence stands at 49.4%. The country has implemented most key cardiovascular disease policies and has a national action plan in place.
13. BelarusDeath Rate per Capita: 0.002
Micronesia has high Coronary Heart Disease (CHD) rates, constituting 19.88% of total deaths. Micronesia's health expenditure accounts for 11% of its GDP, with a GDP per capita of US$3,629 in 2019.
12. MongoliaDeath Rate per Capita: 0.002
Mongolia faces significant challenges with heart disease, notably Ischaemic Heart Disease (IHD), affecting around 14% of individuals aged 15-69. Hemorrhagic stroke incidence is notably higher in Mongolia compared to global rates. Mortality rates for stroke are severe, with over two-thirds leading to death or disability within a year, and one-third resulting in death within 28 days. Initiatives like 'MongPEN' aim to address heart health, but limited resources hinder improvements. The government aims to reduce CVD mortality as part of its Sustainable Development Vision 2030, but challenges in policy implementation and industry engagement remain.
11. VanuatuDeath Rate per Capita: 0.002
Vanuatu stands among the countries with the highest disease deaths per capita. Heart disease prevalence contributes substantially to overall mortality, with ischemic heart disease and stroke being major concerns. Both genders are affected, with adults aged 15-59 bearing a significant burden of cardiovascular diseases like heart attacks and diabetes.
10. MoldovaDeath Rate per Capita: 0.0024
In 2019, Moldova experienced a significant burden of heart disease, with 23,438 deaths attributed to cardiovascular disease. Raised blood pressure affected 26.2% of women and 33.6% of men, while tobacco smoking prevalence was at 23.6%. Circulatory system diseases accounted for 51% of total deaths, with notable rates for conditions like coronary heart disease (314.9 per 100,000) and stroke (159.2 per 100,000).
9. KiribatiDeath Rate per Capita: 0.0024
Kiribati stands among the countries with the highest disease deaths per capita, evidenced by high rates of raised blood pressure (19.0% in women, 24.0% in men) and tobacco smoking prevalence (48.7% among individuals aged 15 and older). The country recorded 2,792 deaths from cardiovascular disease in 2019. Urgent action is needed to implement effective prevention and treatment strategies to improve heart health outcomes in Kiribati.
8. KyrgyzstanDeath Rate per Capita: 0.0024
Kyrgyzstan grapples with a significant burden of cardiovascular diseases (CVD), notably coronary heart disease, which accounts for 32.35% of total deaths, ranking 16th globally. CVD mortality rates have risen over the years, with half of all deaths attributed to CVD in 2011, claiming over 18,000 lives annually. Economic losses from CVD in 2007 were estimated at over 14 billion soms (around 360 million US Dollars), underscoring the need for healthcare system restructuring to address this health crisis comprehensively.
7. Solomon IslandDeath Rate per Capita: 0.0028
In the Solomon Islands, heart disease is the leading cause of death, with cardiovascular diseases claiming numerous lives annually. The National Referral Hospital sees a significant percentage of admissions for heart-related issues, with heart failure alone accounting for 23% of deaths. The GDP per capita was US$2,344 in 2019, with health expenditure accounting for 5% of GDP.
6. AfghanistanDeath Rate per Capita: 0.003
Afghanistan faces high coronary heart disease (CHD) rates, with nearly one in ten adults affected. Factors contributing to this include older age, tobacco use, high cholesterol levels, and inadequate fruit and vegetable consumption. The prevalence of ideal cardiovascular health (ICVH) is low, with over one-third having 5-7 ICVH, 45.7% having 3-4 ICVH, and 20% having 0-2 ICVH.
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Disclosure. None: The 20 countries with the highest disease deaths per capita is originally published on Insider Monkey.
Transient Ischemic Attack (TIA)
A TIA may be short-lasting, but it can be a sign that you are at risk of a stroke in the near future. (Photo Credit: iStock/Getty Images)
A transient ischemic attack (TIA) is similar to a stroke. Your blood delivers oxygen to every part of your body, and your cells need it to survive. If your blood flow gets blocked, it can cause a TIA.
When you have a TIA, the flow of blood to part of your brain gets cut off for just a few minutes. A TIA is also sometimes called a ministroke, but don't let the "mini" part fool you. A TIA can be a sign that a full-blown stroke is on the way. About 1 in 5 people who have a TIA have a stroke within 90 days. And 2 in 5 people who think they've had a TIA actually had a stroke.
If you have symptoms of a TIA or stroke, call 911 or go to the emergency room. It's important to have a medical evaluation within an hour, if possible.
The symptoms of a TIA can happen suddenly. They're similar to early stroke symptoms, but only last from a few minutes up to about a day. They include:
Droopy face. Your eyes or mouth may droop on one side. You may also have trouble smiling.
Speaking problems. Your speech may be slurred, garbled, or hard to understand. It might be difficult to find the right words.
Weak or numb arms. You may have trouble lifting and holding up both arms.
Those are the most obvious symptoms, but you may also notice:
You can have more than one TIA. Each can have different symptoms, based on which part of your brain is affected.
Post-TIA symptoms
After a TIA, you might notice some long-term effects. Since these could impact your work or other daily activities, you may want to tell your employer and loved ones about it.
TIA lasting effects can include:
Fatigue. You can get very tired after a TIA. Fatigue is when your sleepiness is extreme but doesn't get better with rest.
Emotional shifts. After you have a TIA, you might feel shocked or anxious about your well-being. It's important to talk to your friends and family about your anxiety, to help your overall mood. Sharing your feelings can help others better understand what you're going through. Regular exercise can also help get rid of some tension and boost your energy.
If you continue to have physical, memory, or thinking troubles after a TIA, talk to your doctor.
A TIA can happen when a blood clot gets lodged in an artery that supplies blood to your brain. Without regular blood flow, your brain is starved for oxygen and can't work the way it normally does.
That's why you get symptoms like muscle weakness or slurred speech with a TIA. It's like having a clogged fuel line in your car. Your engine can't run if it's not getting gas.
Clots form when you have a buildup of a fatty, waxy substance called plaque in your arteries. A clot can take shape anywhere in your body, and float along until it gets stuck somewhere. If that "somewhere" happens to be an artery that goes to your brain, you can have a TIA.
You can also get a TIA if there's so much plaque in an artery that it severely limits blood flow to your brain, just like a clot.
If you have symptoms of a TIA, it's important to see your doctor right away. A quick diagnosis is important, because it helps figure out what caused your TIA, how your doctor should treat it, and your risk of having a full-blown stroke.
Your doctor might use:
Physical and neurological exams. They'll test your vision, eye movement, speech, language, reflexes, strength, and sensory system. They might also listen to your carotid artery, which is in your neck, using a stethoscope. This will tell your doctor if you have hardening of the arteries. Your doctor may also use an ophthalmoscope to check for fragments of cholesterol or platelets in the blood vessels at the back of your eyes.
Your doctor will also look for other stroke risk factors like high cholesterol, high blood pressure, diabetes, or high homocysteine (an amino acid that can signal low levels of B vitamins and/or heart disease).
Computerized tomography (CT) or computerized tomography angiography (CTA) scans. These use X-rays to make a 3D image of the brain, along with the arteries in your neck and brain.
Carotid ultrasonography. If your doctor thinks your carotid artery caused your TIA, they'll use this tool to look closely at any narrowing or clotting in your neck. An ultrasound uses high-frequency sound waves to create images of the arteries that will show clots.
Magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA). These tests use a magnetic field to help your doctor check your brain, arteries, and neck. With an MRA, your doctor will inject a contrast material into your blood vessel to get a better image of your arteries.
Echocardiography. This tool allows your doctor to look clearly at possible causes, like blood clots, through an ultrasound image. This is used to see if the cause of your TIA might be an issue with your heart.
Arteriography. This helps your doctor look at arteries in your brain that usually aren't seen on an X-ray. Your doctor will put a thin tube (catheter) in a small cut in your leg. The tube is moved to the brain, where it injects dye to get a better view of the brain on an X-ray.
After you have a TIA, the goal of treatment is to lower your risk of a having a stroke in the future. Your doctor will decide on your treatment based on what caused the TIA. Treatment will depend on things like the location of the clot, how serious the TIA was, and findings of an MRI or CT scan.
TIA medications
Your doctor will likely recommend medication for you after a TIA. Medications are prescribed to treat the cause of the TIA and prevent a stroke.
Anti-platelet drugs. Aspirin is the most commonly recommended medication after a TIA because it is inexpensive, you can get it over the counter, and it has few side effects. Other anti-platelet medications that your doctor may prescribe include clopidogrel (Plavix), ticagrelor (Brilinta), and Aggrenox (a combination of aspirin and dipyridamole). Your doctor may recommend you take aspirin and one of these medications for a short time after your TIA to reduce the risk of a stroke. Anti-platelet drugs make platelets less sticky, so they won't clump together and form blood clots.
Anticoagulant drugs. Your doctor may prescribe one of these medications. They thin your blood, making it less likely to clot. Blood thinners are usually prescribed if you had a blood clot in your heart or have a condition known as atrial fibrillation (irregular heart rhythm). Anticoagulants include apixaban (Eliquis), dabigatran (Pradaxa), heparin, rivaroxaban (Xarelto), and warfarin (Coumadin, Jantoven).
Statins. Statins are medications used for lowering cholesterol. Research has also shown that statins may help keep blood vessels healthy and hinder blood clotting. Statins include atorvastatin (Lipitor), fluvastin (Lescol XL), rosuvastatin (Crestor), and simvastatin (Zocor).
Blood pressure medications. Your doctor may prescribe one of these medications, which help expand blood vessels and allow for better blood flow. There are several medications in this class, including calcium channel blockers like amlodipine (Norvasc), angiotensin-converting enzyme (ACE) inhibitors like benazepril (Lotensin), angiotensin II receptor blockers (ARBs) including candesartan (Atacand), and diuretics.
Your doctor may also recommend an endovascular procedure (which means inside a blood vessel). With these, a narrow tube is inserted into a vessel through a small cut, usually in your groin. These procedures include:
If medication and endovascular procedures aren't enough, your doctor may recommend surgery. If one of the carotid arteries in your neck is narrowed or blocked, your doctor may perform surgery to clear it out and restore normal blood flow. One option is an operation called a carotid endarterectomy, where your doctor opens up your carotid artery, scrapes out the plaque, and closes it back up.
If you have a TIA, you are more likely to have a heart event or other conditions not related to your heart shortly afterward. In fact, you are more likely to have some kind of complication as soon as 30 days after your TIA. Possible complications include:
Stroke. You have about a 3% chance of having a stroke after a TIA, and they happen more frequently within 30 days.
Acute coronary syndrome. Having a TIA also increases your risk of having chest pain or a heart attack within 30 days.
Ventricular arrhythmia. A fast heartbeat because of unusual electrical activity is also more common after a TIA.
Blood clot. You are more likely to have another blood clot, including deep vein thrombosis, where you have a blood clot in a deep vein, after a TIA.
Acute heart failure. After a TIA, your risk goes up within 90 days.
Non-cardiovascular complications
Having a TIA also increases your risk of other conditions, including depression, problems swallowing, urinary tract infections, and falls.
Although symptoms of a TIA only last for a short period of time, you may have some lasting effects from a TIA. Your doctor can help you understand the best plan to keep you healthy and prevent complications after you have a TIA.
Avoid driving. Your doctor will probably tell you not to drive for 1 month after having a TIA. If you have had a full recovery after 1 month, your doctor should allow you to get back behind the wheel.
Go to follow-ups. Go to all of your follow-up appointments your doctor schedules and take any medications they prescribe regularly.
Avoid getting sick. Try to avoid getting colds and the flu by taking vaccines that are right for you, including those for the flu, pneumonia, and COVID-19.
Focus on your health. It's important to follow treatment advice from your doctor and consider healthy lifestyle changes. If you smoke, stop or enroll in smoking cessation classes; drink less alcohol or none at all; eat a balanced diet, including plenty of fruits and vegetables, whole grains, and lean meats; and try to get 150 minutes of physical activity each week. All of these things can help lower your risk of a stroke.
Manage depression. Depression, apathy, and anxiety can last for a year or more after a TIA. These feelings can be due to changes in the brain from the TIA or from the emotional trauma of having a major health event. Symptoms to watch for include:
Managing your depression or anxiety can increase your chances of a healthy recovery. If you feel like you may be dealing with either condition, talk to your doctor about treatment options.
To prevent a TIA, make these healthy lifestyle choices:
Eat food that's good for you. Choose whole foods, meaning those that are as natural and unprocessed as possible. Also eat a low-fat, low-salt, high-fiber diet with plenty of fruits and veggies. Limit saturated fats and sugar , and avoid trans fats.
Get a good night's sleep. Regular shut-eye can lower your risk of a stroke. Create a routine to relax at night and try to get the recommended 7-9 hours of sleep each night. If you have sleep apnea – where your breathing stops frequently during the night before quickly restarting – talk to your doctor about getting the condition treated.
Limit alcohol. If you drink, keep it to one drink a day if you're female, or two if you're male.
Manage your other health conditions. The more you control issues like high blood pressure, diabetes, and atrial fibrillation, the better.
Stick to an exercise routine. Typically, you need at least 150 minutes of medium-level cardio, like brisk walking, each week. Check with your doctor to see what's safe for you.
Stay at a healthy weight. If you are unsure of what weight is best for you, a good range is a body mass index of 18.5 to 24.9. (For example, a person who is 5 feet, 9 inches tall could weigh from 125 to 168 pounds and be in this range.) Another measure to take could be waist size. For men or people assigned male at birth (AMAB), waist circumference should be 40 inches or less. For women or people assigned female at birth (AFAB), waist size should be 35 inches or less. This will help with your blood pressure and cholesterol, too.
Stop smoking. Tobacco harms your health in many ways, including raising your stroke risk.
Avoid illegal drugs. Drugs like amphetamines, cocaine, and heroin can raise your chances of a TIA or stroke.
Along with other lifestyle changes, if you're a biological woman, you should take a few more steps to avoid a TIA or stroke. For instance, if you're over age 75, ask your doctor to check you for atrial fibrillation.
If you're pregnant, have your blood pressure checked regularly during and after pregnancy.
If you think you might start birth control pills, get checked for high blood pressure first.
If you get migraines with auras, it's even more important that you stop smoking right away.
TIAs are similar to ischemic strokes, which are also caused by blood clots.
The main difference is that a TIA only lasts a few minutes. Then, chemicals in your body quickly break down the clot or it gets pushed along, like a temporary clog in a pipe. Normal blood flow returns to your brain without causing permanent damage. Symptoms, which are similar to the those of a stroke, can last for up to 24 hours, but they're usually gone in an hour.
Strokes, on the other hand, don't go away so quickly. That means some part of your brain goes without oxygen, and the longer that lasts, the more damage happens. While a TIA comes on, goes away, and leaves no symptoms, a stroke can have long-lasting effects and can be life-threatening.
A TIA can affect anyone. The same things that raise your odds of having a stroke also affect your risk of a TIA, and there are a lot of issues in play.
Risks you can't control. Some things you can't change, but it's helpful to be aware of them:
Health conditions. Other medical problems you have can also increase the odds of having a TIA, including:
Lifestyle. Some of the choices you make every day may affect your chances of having a TIA. You may have a higher risk if you:
Risks for women. Odds of a TIA may be higher for women who:
A TIA is also called a ministroke because it usually only lasts for several minutes. But it's important to get medical help right away if you have stroke symptoms. A TIA is often a warning sign of a full-blown stroke.
Is A TIA life-threatening? No, but it can mean you are more likely to have a stroke in the near future. If you have symptoms, call 911 or go to the emergency room.
What is the life expectancy after having a TIA? A TIA doesn't do any long-term damage to your brain or cause permanent disability.
What happens if a ministroke goes untreated? You will be more likely to have more ministrokes or an ischemic stroke in the future.
Cleerly® ISCHEMIA™ Demonstrates Robust Diagnostic Accuracy And Prognostic Utility In Analyses From Large Scale Clinical Trials
CREDENCE and PACIFIC-1 study data demonstrate potential power of AI-QCT ISCHEMIA
DENVER–(BUSINESS WIRE)–Cleerly, the company on a mission to create a new standard of care to aid in the diagnosis of heart disease, shared findings from a study published online in the Journal of the American College of Cardiology: Cardiovascular Imaging on March 13, 2024. The study describes the validation of Cleerly's artificial intelligence-guided quantitative coronary CT angiography (AI-QCT) ISCHEMIA technology for diagnostic accuracy and prognostic risk stratification.
In two trials,1-2 the CREDENCE and PACIFIC-1 studies comprised a total of 513 patients who underwent coronary CT angiography, myocardial perfusion imaging with single photon emission CT (SPECT), and fractional flow reserve derived from CT (FFRCT). For patients with an abnormal Cleerly AI-QCT ISCHEMIA finding, a positive result was associated with an approximately 7-fold increase of adverse cardiovascular events during an 8-year follow-up. Collectively, this study shows that Cleerly AI-QCT ISCHEMIA, when used in conjunction with Cleerly LABS, can provide a 3-in-1 approach for the assessment of atherosclerosis, stenosis and ischemia.
"This pivotal study was performed in two different international populations which shows that CCTA analyzed with the Cleerly AI-QCT ISCHEMIA device provides an accurate assessment of coronary ischemia," said James P. Earls, MD, Chief Medical Officer of Cleerly. "These promising findings offer the possibility of a novel care paradigm for symptomatic coronary artery disease evaluation that performs comprehensive analysis of atherosclerosis, stenosis and ischemia from a single non-invasive CCTA test, which may offer the benefit of guiding clinical decision making for both coronary revascularization and medical therapy."
These study results come after Cleerly announced that its Cleerly ISCHEMIA software device is billable using the new Category I CPT® code 75580.
About Cleerly®
Cleerly is the company on a mission to eliminate heart attacks by creating a new standard of care for heart disease. Through its FDA-cleared solutions driven by artificial intelligence, Cleerly supports comprehensive phenotyping of coronary artery disease, as determined from advanced non-invasive CT imaging. Cleerly's approach is grounded in science, based on over 10 million images from over 40,000 patients gathered over a 15-year-period in landmark, multi-center clinical trials. Led by a world-class clinical and technical team, Cleerly enhances health literacy for each and every stakeholder in the coronary care pathway. For more information, please visit: www.Cleerlyhealth.Com.
Disclaimer:
Cleerly ISCHEMIA is an add-on software module to Cleerly Labs that determines the likely presence or absence of coronary vessel ischemia, with the thresholds equivalent to invasive FFR ≤0.80 vs. >0.80, respectively. This threshold was chosen in accordance with the American Heart Association / American College of Cardiology professional societal guidelines that advocate for the use of FFR ranges at the 0.80 level to be used to guide clinical decision making for determining appropriateness of coronary revascularization.3 The diagnostic performance of Cleerly ISCHEMIA for non-invasive determination of the functional significance of CAD has been validated against direct invasive measurement of FFR.2
Cleerly ISCHEMIA prediction is based on coronary lesion morphology and plaque characteristics from CCTA imaging. It is a clinical decision support tool that should be used with the entirety of relevant patient specific data when making a diagnosis or clinical decision.
References:
Disclosures:
This study was sponsored by Cleerly, Inc. And journal article authors Hao Wang, MS; Chung Chan, PhD; Tami Crabtree, MS; Melissa Aquino, MS; James K. Min, MD; and James P. Earls, MD are employees of Cleerly, Inc.
Contacts
Cleerly Press
press@cleerlyhealth.Com
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