5 Things We Now Know About Pulmonary Arterial Hypertension
Lung Disease News
Dec. 12, 2023 — By monitoring changes in circulating tumor DNA (ctDNA) among 30 patients treated with immunotherapies for metastatic non-small cell lung cancers, researchers were able to determine molecular response ...
Dec. 11, 2023 — Advancements in the care of premature babies are leading to improved survival rates. However, the incidence of neonatal diseases with life-long consequences such as bronchopulmonary dysplasia (BPD) ...
Dec. 6, 2023 — Researchers have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC). And in an early parallel study in humans, ...
Nov. 29, 2023 — The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer and for which licensed drugs could be clinically trialed to find out if they ...
Nov. 17, 2023 — Research shows that some lung cancer cells retain a 'memory' of the healthy cell where they came from -- one that might be exploited to make an emerging type of lung cancer treatment ...
Nov. 14, 2023 — A new study has discovered asbestos exposure led to a higher incidence of asbestos-related lung cancers in British and Australian naval personnel than in other armed ...
Nov. 13, 2023 — Despite the Centers for Disease Control and Prevention warning this year will be potentially dangerous for respiratory illnesses, a third of Americans are not concerned about the threat, according to ...
Sep. 27, 2023 — Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF ...
Sep. 27, 2023 — Lung fibrosis is a debilitating disease affecting nearly 250,000 people in the U.S. Alone with 50,000 new cases reported each year. There is currently no cure and limited available treatment options, ...
Sep. 21, 2023 — Scientists have shown that their steerable lung robot can autonomously maneuver the intricacies of the lung, while avoiding important lung ...
Sep. 21, 2023 — Small cell lung cancer accounts for about 15 percent of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumours often develop resistance to chemotherapy and thus ...
Sep. 13, 2023 — During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or ...
Sep. 12, 2023 — Pneumonia is an infection of the lung alveoli caused by bacteria, viruses or fungi. It is one of the leading causes of morbidity and mortality worldwide, representing a clinical and economic burden ...
Sep. 12, 2023 — An international team of researchers has demonstrated that a combination of inhibitors may suppress tumor growth and prevent relapse in patients with certain cancers, including head and neck squamous ...
Sep. 7, 2023 — Women exposed to air pollution give birth to smaller babies, according to new research. The research also shows that women living in greener areas give birth to bigger babies and this may help ...
Sep. 7, 2023 — Researchers reveal for the first time that high blood sugar levels in type 2 diabetes can play a causal role in lung ...
Sep. 5, 2023 — A new study has shown that a subtype of avian flu virus, endemic in poultry farms in China, is undergoing mutational changes, which could increase the risk of the disease being passed on to ...
Aug. 30, 2023 — Fresh discoveries about a type of immune cells could give lung cancer patients a more accurate prognosis and better identify who will benefit from immunotherapies. Researchers found that the location ...
Aug. 25, 2023 — High levels of some minerals and metals in environmental water supplies may increase the risk of nontuberculous mycobacteria (NTM) pulmonary infections in people with cystic fibrosis, according to a ...
Aug. 24, 2023 — Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary ...
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Roche Explores Selling Lung Disease Drug Amid Buyer Interest
(Bloomberg) -- Roche Holding AG is considering selling Esbriet, a lung disease drug that's seen sales plummet amid competition from cheaper generics.
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The Swiss pharmaceuticals giant is in the early stages of evaluating a disposal after getting inbound interest from potential suitors, people with knowledge of the matter said, asking not to be identified discussing confidential information.
Esbriet is an oral anti-fibrotic medicine used to treat a chronic lung disease known as idiopathic pulmonary fibrosis. Sales of the drug fell more than 70% to 202 million Swiss francs ($229 million) in 2023.
"As part of the normal process to review our portfolio of established products, we are currently evaluating potential options for Esbriet," a spokesperson for Roche said in response to Bloomberg queries. "This process will take several months until a final decision is taken."
Large pharmaceuticals firms are keen to dispose of non-core assets as they seek to prune portfolios and focus on growth areas. Roche's rival Novartis AG agreed in June to sell part of its portfolio of eye medicines to Bausch + Lomb Corp. In a deal worth as much as $2.5 billion. Buyout firms, including Advent International and Blackstone Inc., are circling the consumer health division of French pharmaceutical giant Sanofi ahead of a potential separation of the business, Bloomberg News reported in February.
Esbriet is available in about 40 countries, according to information on Roche's website. Roche Chief Executive Officer Thomas Schinecker has clinched several deals to replenish the company's pipeline in recent months, expanding its footprint beyond the cancer therapies that long anchored its business. Still, Roche has forecast a sluggish recovery in sales and earnings this year as it emerges from a difficult 2023 and a string of research setbacks.
Story continues
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Bacteria In The Mouth Linked To Pulmonary Fibrosis Survival
Bacteria in the mouth may play a role in survival from idiopathic pulmonary fibrosis (IPF), finds a new study led by researchers from the University of Michigan and the University of Virginia.
The findings come from a larger analysis of the role of the lung microbiome and IPF. Working under the hypothesis that treatment with antibiotics could improve outcomes in patients with the disease, the CleanUP-IPF study includes the collection of cheek swabs and other samples to examine changes in bacterial populations.
David O'Dwyer, M.D., Ph.D., of the Division of Pulmonary and Critical Care Medicine at U-M Medical School, partnering with John Kom, M.D. And Imre Noth, M.D., of the University of Virginia and their team, saw an opportunity to also study the role of the oral microbiome in lung disease, as it is now generally accepted that bacteria from the mouth and throat are a major contributor to the lung microbiome.
Using 16S rRNA analysis and other genetic techniques, the team extracted DNA from the cheek swabs to look for clues.
Surprisingly, they found that one bacterial species, Streptococcus mitis, tended to dominate in certain patients with IPF who were not treated with antibiotics. What's more, those patients had better lung function and less severe disease -- and ultimately, were more likely to survive.
To date, research has shown that a more diverse set of bacteria in the lungs and in the gut is reflective of better health. That does not hold true for the mouth, however, noted O'Dwyer. Streptococcus mitis tends to act as a gatekeeper toward other bacterial threats, including those that can cause periodontal disease, he said.
The team notably did not find the same protective relationship between oral Streptococcus mitis and IPF in patients who had received antibiotics. Future studies aim to further determine the various bacterial populations within the oral and lung environment in patients with IPF to understand the link between these microbiomes and disease.
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