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Medications And Their Potential To Cause Increase In 'Acute Pulmonary Oedema'

' as a side effect." It's important to note that mild side effects are quite common with medications.

Please be aware that the drugs listed here are individual medications and may be part of a broader combination therapy. This information is meant to be a helpful resource but should not replace professional medical advice. If you're concerned about '

', it's best to consult a healthcare professional.

', other symptoms or signs might better match your side effect. We have listed these below for your convenience. If you find a symptom that more closely resembles your experience, you can use it to identify potential medications that might be the cause.

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bosutinib , nifedipine , docetaxel , ixabepilone , nebivolol , oxytocin , 5-FU , gadobenate Find drugs that can cause other symptoms like 'Acute pulmonary oedema'

How To Be Active In Your Treatment Journey With COPD

Gordon Stewart-Harrison recalls his first experience with chronic obstructive pulmonary disease (COPD) when he was shoveling snow on his driveway. After just a few moments, he was completely out of breath and had to sit down because he feared he would fall.

"It was truly frightening," he says.

Gordon didn't know at the time that this episode was caused by COPD, a progressive disease that damages lungs and makes it hard to breathe.1 Looking back, he recognizes there were many missed signs prior to this flare-up, also known as a COPD exacerbation. Flare-ups are characterized by worsening COPD symptoms that require medical attention.2

Now, a decade later, Gordon is managing his condition well and says he hasn't had a flare-up for more than a year. He can do the things he loves and credits his improved health to having a better understanding of the disease and an open line of communication with his doctor.

"You can live a very fulfilling life with COPD and don't have to be held back by this disease," he explains. "But being active in your treatment journey is key."

Throughout his COPD journey, Gordon has learned a lot about his condition from personal experiences, doctors, and loved ones. As a COPD advocate, Gordon now wants to help others with the disease by sharing his insights so that other patients can live their lives to the fullest.

Recognize Ongoing Symptoms – a Sign of COPD Progression

Early warning signs of COPD include chronic and progressive labored breathing, coughing, coughing up phlegm, chest tightness, and wheezing.3 These are often mistaken as typical effects of aging. However, symptoms can progress rapidly, so it's vital to see a healthcare provider immediately if they arise.

Gordon says he didn't know much about COPD before being diagnosed, which led to missing symptoms and the disease progressing.

"Prior to my first flare-up, there were moments when I was out of breath," he says. "Regular activities like being an usher or handing out programs at my church became a struggle, and washing my car took great effort, so I thought I just needed to exercise more."

Knowing the risk factors is also important. The leading cause of COPD is smoking, something Gordon said he did for many years. However, other risk factors include experiencing respiratory infections as a child and being exposed to air pollution, secondhand smoke, chemical fumes, or dust.4

Advocate for Yourself to Get the Care and Support You Need

Following Gordon's frightening first flare-up, his primary care provider (PCP) suspected he may have COPD and connected him with a pulmonologist, who confirmed the diagnosis.

He says his relationship with his PCP and working closely with a trusted specialist have been cornerstones in his treatment. Gordon's pulmonologist prescribed him medications, taught him techniques to strengthen his breathing muscles, and showed him how to use an oxygen concentrator, which Gordon now keeps with him as a precautionary measure. An oxygen concentrator is a device that provides 90-95% pure oxygen for people who need it for medical reasons.5

Since COPD is a progressive disease, symptoms often evolve over time, and it's important for patients to monitor and effectively communicate changes and the impact of symptoms to their doctor. For Gordon, this included recognizing when his treatment was not working. He tried different medications that required multiple daily doses over the years. Unfortunately, he didn't notice a change in how he felt, and he still experienced periodic flare-ups.

"I asked my doctor what I was supposed to feel from the medication and let him know when I didn't feel any different than before," Gordon says.

This open line of communication led his doctor to prescribe TRELEGY ELLIPTA (fluticasone furoate 100 mcg, umeclidinium 62.5 mcg, and vilanterol 25 mcg inhalation powder), a once-daily treatment for COPD that contains three medicines in a single inhaler.

TRELEGY is a prescription medicine used long term to treat COPD, including chronic bronchitis, emphysema, or both. Not for sudden breathing problems and won't replace a rescue inhaler. Tell your doctor if you have a heart condition or high blood pressure before taking. Do not take more than prescribed. May increase your risk of thrush, pneumonia, and osteoporosis. Call your doctor if worsened breathing, chest pain, mouth or tongue swelling, problems urinating, vision changes, or eye pain occur. Please see additional Important Safety Information below.

After that, he finally began to feel better.

"I started taking TRELEGY and within a few months, I noticed my symptoms had improved," says Gordon. TRELEGY can help improve lung function for a full 24 hours and prevent future flare-ups, though individual results may vary.

Taken only once a day, TRELEGY contains an anti-inflammatory ICS (inhaled corticosteroid) that reduces inflammation and swelling in the lungs, a LABA (long-acting beta2-adrenergic agonist) bronchodilator that opens airways by relaxing the muscles around the airways in the lungs, and a LAMA (long-acting muscarinic antagonist) that blocks the tightening of smooth muscle around airways to help keep them open.

Advocating for yourself extends beyond doctor's appointments. Gordon says that another key part of staying healthy is knowing his limits. When he plans to attend a sporting event, he alerts staff of his medical condition in advance to allow for closer parking and elevator access. At work, he no longer uses the stairs, and has told his colleagues about his diagnosis, so they can help him with the physically taxing tasks he no longer feels comfortable doing.

"I had to make changes to my life," Gordon says. "But I know these are necessary in order to live the active life I want and that feels good."

Do the Work to Make a Positive Impact on Your Symptom Management

While prescription medication and a home oxygen concentrator play an essential role in treating his COPD, lifestyle factors have a significant impact as well, Gordon says. He is dedicated to doing the breathing exercises his doctor taught him and goes to the gym weekly, taking his oxygen machine along with him.

"Going to the gym strengthens my mental and physical health and has become a valuable part of my daily routine," he says. In general, moderate exercise has many benefits for people with COPD as it helps improve the body's use of oxygen, energy levels, mental health, sleep, self-esteem, cardiovascular fitness, muscle strength, and shortness of breath.6 Talk to your healthcare provider about how much exercise and the types of exercise that are best for you.

Eating heart-healthy foods, having more frequent, smaller meals instead of three bigger meals, and minimizing foods that cause bloating or gas, which can make breathing more difficult, all play a vital role in COPD treatment.7

Being diagnosed with COPD has prompted Gordon to make some changes, but he emphasizes that he still lives a very full, happy life.

"You just have to be mindful that you can take control of this disease and your life," he says. "You don't have to give in to it."

To find out more about COPD and TRELEGY, visit TRELEGY.Com or talk with your healthcare provider.

Important Safety Information for TRELEGY

Do not use TRELEGY to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.

Do not use TRELEGY if you have a severe allergy to milk proteins or are allergic to any of the ingredients in TRELEGY. Ask your healthcare provider if you are not sure.

Do not use TRELEGY more often than prescribed.

Do not take TRELEGY with other medicines that contain a long-acting beta2-adrenergic agonist (LABA) or an anticholinergic for any reason. Tell your healthcare provider about all your medical conditions and about all the medicines you take.

Call your healthcare provider or get medical care right away if your breathing problems get worse, if you need your rescue inhaler more often than usual or it does not work as well to relieve your symptoms.

TRELEGY can cause serious side effects, including:

Common side effects of TRELEGY 100/62.5/25 mcg for COPD include: upper respiratory tract infection; pneumonia; bronchitis; thrush in your mouth or throat (rinse your mouth with water without swallowing after use to help prevent this); headache; back pain; joint pain; flu; inflammation of the sinuses; runny nose and sore throat; taste disturbance; constipation; painful and frequent urination (signs of a urinary tract infection); nausea, vomiting, and diarrhea; mouth and throat pain; cough; and hoarseness.

Please see full Prescribing Information, including Patient Information, for TRELEGY.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.Fda.Gov/medwatch, or call 1-800-FDA-1088.

For US audiences only.

For more information, please visit trelegy.Com.

Trademarks are owned by or licensed to the GSK group of companies.

©2023 GSK or licensor.FVUADVR230003 October 2023Produced in USA.

Sources

National Heart, Lung, and Blood Institute. COPD - What Is COPD?NHLBI, NIH. Www.Nhlbi.Nih.Gov. Published 2022. Https://www.Nhlbi.Nih.Gov/health/copd

What is a COPD Exacerbation?COPD.Com. Published 2019. Https://www.Copd.Com/copd-progression/copd-exacerbations/

‌Agarwal AK, Raja A, Brown BD. Chronic obstructive pulmonary disease (COPD). National Library of Medicine. Published August 7, 2023. Https://www.Ncbi.Nlm.Nih.Gov/books/NBK559281/

COPD causes and risk factorsAmerican Lung Association. Www.Lung.Org. Published April 28, 2023. Https://www.Lung.Org/lung-health-diseases/lung-disease-lookup/copd/what-causes-copd

What Is an Oxygen Concentrator?Cleveland Clinic. Published August 4, 2023. Https://my.Clevelandclinic.Org/health/treatments/25183-oxygen-concentrators

Physical Activity and COPDAmerican Lung Association. Www.Lung.Org. Published May 23, 2023. Https://www.Lung.Org/lung-health-diseases/lung-disease-lookup/copd/living-with-copd/physical-activity

Nutrition and COPDAmerican Lung Association. Www.Lung.Org. Published May 23, 2023. Https://www.Lung.Org/lung-health-and-diseases/lung-disease-lookup/copd/living-with-copd/nutrition.Html

Everything You Need To Know About Lung Cancer

Lung cancer is a cancer that starts in the lungs and can spread to other areas of the body. The symptoms, outlook, and treatment depend on the stage of cancer and how far it has spread.

Lung cancer is the leading cause of cancer deaths in the United States. Early symptoms of lung cancer can be subtle, but the sooner it is diagnosed, the better your treatment options and possible outcomes.

Doctors primarily treat lung cancer with surgery, chemotherapy, and radiation. Newer treatments include immunotherapy and targeted therapy.

Read on to learn more about lung cancer and the current and evolving treatment options.

The symptoms of lung cancer depend on the type and stage of your cancer:

What does stage 1 lung cancer feel like?

The early stages of lung cancer don't always cause symptoms. When early symptoms do occur, they can include shortness of breath as well as unexpected symptoms, such as back pain.

Back pain can occur when tumors cause pressure in your lungs or when they spread to your spinal cord and ribs.

Other early signs of lung cancer may include:

a lingering or worsening cough

coughing up phlegm or blood

chest pain that worsens when you breathe deeply, laugh, or cough

hoarseness

wheezing

weakness and fatigue

loss of appetite and weight loss

recurrent respiratory infections such as pneumonia or bronchitis

What do later stages of lung cancer feel like?

Additional symptoms of lung cancer depend on where new tumors form. Not everyone with late-stage lung cancer will experience every symptom.

Late-stage symptoms might include:

lumps in your neck or collarbone

bone pain, especially in your back, ribs, or hips

headaches

dizziness

balance issues

numbness in arms or legs

yellowing of skin and eyes (jaundice)

drooping of one eyelid and shrunken pupils

lack of perspiration on one side of your face

shoulder pain

swelling of your face and upper body

Additionally, lung cancer tumors can sometimes release hormones, leading to a wide variety of symptoms known as paraneoplastic syndrome. Symptoms include:

There are several different types of lung cancer. Most types of lung cancer are either non-small cell lung cancer (NSCLC) or small-cell lung cancer (SCLC). However, some people have tumors that contain both kinds of cells.

Non-small cell lung cancer (NSCLC): NSCLC makes up about 80–85% of all cases. There are several types of NSCLC. Most types of NSCLC respond well to treatment if caught in the early stages.

Squamous cell lung carcinoma: About 30% of all cases of NSCLC begin in the cells that line the passages of your respiratory tract. This is called squamous cell carcinoma.

Adenocarcinomas: This type usually forms in the outer part of your lungs.

Adenocarcinoma in situ (AIS): This rare subset of adenocarcinoma begins in the tiny air sacs in your lungs. It's not aggressive and may not need immediate treatment.

Adenosquamous carcinoma: This cancer develops in a mixture of squamous cells and mucus-producing cells.

Large cell carcinoma: Large cell carcinoma is a fast-growing group of NSCLCs that does not classify under other cancer types.

Small-cell lung cancer (SCLC): About 15–20% percent of lung cancers are SCLC. This type of lung cancer is more aggressive than NSCLC. Although SCLC often initially responds better to chemotherapy, it is less likely to be cured than NSCLC.

Mesothelioma: This type of lung cancer has links with asbestos exposure. It occurs when carcinoid tumors start in hormone-producing (neuroendocrine) cells. Mesothelioma is aggressive and fast-growing. It does not respond well to treatment.

Learn how lung cancer type can affect survival rates.

Cancer stages tell how far cancer has spread and help guide treatment.

The chance of successful or curative treatment is much higher when lung cancer is diagnosed and treated early. Because lung cancer may not cause obvious symptoms in the earlier stages, people usually receive a diagnosis after it has spread.

Non-small cell lung cancer (NSCLC) stages:

Hidden (occult): For unknown reasons, doctors cannot identify the tumor, but cancer cells are visible in sputum or other fluid tests. Testing also suggests the cancer has not spread to nearby lymph nodes or other places.

Stage 0: The cancer is only present in the epithelial layer of cells covering the airway, with no evidence that it has gone deeper into the lung tissues, nearby lymph nodes, or any other parts of the body.

Stage 1: Cancer is found in the lungs but has not spread to the lymph nodes or anywhere else.

Stage 2: Cancer is in the lung and nearby lymph nodes.

Stage 3: Cancer is in the lung and lymph nodes in the middle of the chest.

.Stage 4: Cancer has spread to both lungs, into the area around the lungs, or to distant organs.

All of these stages can divide into substages depending on the type of tumor, its size, and the specific structures it affects.

Small-cell lung cancer (SCLC) stages:

There are two stages of SCLC: limited and extensive. In the limited stage, cancer is found in only one lung or nearby lymph nodes on the same side of the chest.

The extensive stage means cancer has spread:

throughout one lung

to the opposite lung

to lymph nodes on the opposite side

to fluid around the lung

to bone marrow

to distant organs

About 2 out of 3 people with SCLC are already in the extensive stage when they receive a diagnosis.

The following are the estimated 5-year survival rates for NSCLC and SCLC by SEER stage:

Small-cell lung cancer (SCLC) is very aggressive. Depending on how far the cancer has spread, the relative 5-year survival rate for mesothelioma is 7–24%.

Keep in mind that survival rates and other statistics provide a broad picture of what to expect. There are significant individual differences, and your doctor is in the best position to discuss your outlook.

Learn more about the prognosis for non-small cell lung cancer.

The U.S. Preventative Task Force (USPSTF) recommends people ages 50–80 years who currently smoke or those who have quit in the last 15 years undergo screening for lung cancer.

The screening is usually done with a low dose computed tomography (CT), though your doctor may want to conduct other imaging tests such as X-ray, MRI, and PET scans, which can also show an abnormal mass in your lungs.

In addition, they may conduct the following tests:

Sputum cytology: If you produce phlegm when you cough, a microscopic examination can determine if cancer cells are present.

Bronchoscopy: While under sedation, doctors pass a lighted tube down your throat and into your lungs, allowing closer examination of your lung tissue.

Thoracentesis: If there is fluid in your lungs, this procedure can remove some of the fluid to see if the cancer has spread to the lining of your lungs.

Lung needle biopsy: This involves obtaining a small sample of lung tissue, which is then examined under a microscope to see if tumor cells are cancerous. Your doctor inserts a needle through the chest wall and into the suspicious lung tissue. There are various sub-types of this procedure depending on your specific needs.

If the biopsy results are positive for cancer, you might need additional testing, such as a bone scan, to help determine if the cancer has spread and to help with staging.

Learn more about how doctors diagnose lung cancer.

The primary treatments for lung cancer include surgery to remove the tumor and chemotherapy and radiation treatments to kill cancer cells. Sometimes, doctors use newer cancer treatments such as targeted therapy and immunotherapy, but usually not until later stages.

As a rule, treatment for NSCLC varies from person to person. Your treatment plan will depend on specific details of your health and at what stage you received a diagnosis.

Treatment options for NSCLC by stage typically include:

Stage 1 NSCLC: Surgery to remove a portion of the lung may be all you need. Your doctor may also recommend chemotherapy, especially if you're at high risk of recurrence. Cancer is most treatable if caught at this stage.

Stage 2 NSCLC: You may need surgery to remove part or all of your lung. Your doctor will usually recommend chemotherapy.

Stage 3 NSCLC: You may require a combination of chemotherapy, surgery, and radiation treatment.

Stage 4 NSCLC: Options include surgery, radiation, chemotherapy, targeted therapy, and immunotherapy.

The options for SCLC also include surgery, chemotherapy, and radiation therapy. In most cases, the cancer will be too advanced for surgery.

If you're diagnosed with lung cancer, it's likely that a team of doctors will manage your care, including:

a surgeon who specializes in the chest and lungs (thoracic surgeon)

a lung specialist (pulmonologist)

a medical oncologist

a radiation oncologist

Discuss all your treatment options before making a decision. Your doctors will coordinate care and keep each other informed. You may also want to discuss clinical trials with your doctor.

Clinical trials can provide access to promising new treatments and can be an option if your treatment plan has stalled.

Some people with advanced lung cancer choose not to continue treatment. You can still choose palliative care treatments, which focus on treating the symptoms of cancer rather than the cancer itself.

Learn more about alternative treatments for lung cancer.

Home therapies for lung cancer symptoms

Home remedies won't cure cancer. However, some may help relieve symptoms associated with lung cancer or the side effects of treatment.

Options may include:

Massage: Massage can help relieve pain and anxiety. Some massage therapists have specific training to work with people with cancer.

Acupuncture: When performed by a trained practitioner, acupuncture may help ease pain, nausea, and vomiting. However, it's not safe if you have low blood counts or take blood thinners.

Meditation: Relaxation and reflection may help reduce stress and improve overall quality of life.

Yoga: Combining breathing techniques, meditation, and stretching, yoga can help you feel better overall and improve sleep.

Cannabis oil: Some people claim that cannabis oil reduces pain, relieves nausea and vomiting, and improves appetite. However, scientists need to do more research into these claims. Additionally, state laws on cannabis vary, so this option isn't available nationwide.

Diet recommendations for people with lung cancer

No diet can minimize lung cancer. However, it's important to get all the nutrients your body needs.

Cancer treatments can cause you to lose your appetite. They can also make it hard for your body to absorb vitamins. If you're deficient in certain nutrients, your doctor can advise you on foods or supplements as necessary.

Here are a few dietary tips:

Eat whenever you have an appetite.

If you don't have an appetite, try eating smaller meals throughout the day.

If you need to gain weight, supplement with low sugar, high calorie foods and drinks.

Use mint and ginger teas to soothe your digestive system.

If your stomach is easily upset or you have mouth sores, avoid spicy food.

If you have constipation, try adding more high fiber foods.

As you progress through treatment, your tolerance to certain foods may change. So can the side effects you experience and your nutritional needs. It's worth discussing nutrition with your doctor. You can also ask for a referral to a nutritionist or dietician.

Here's how to meet your dietary needs if you have lung cancer.

Anyone can get lung cancer, but there are a few risk factors that make it a lot more likely.

Smoking

Smoke damages your lung tissue from the moment you inhale it. Once you have damage to your lung cells, they begin to behave abnormally. This increases your chance of lung cancer.

Smoking is the single biggest risk factor for lung cancer. This includes cigarettes, cigars, and pipes. Tobacco products contain thousands of toxic substances.

As many as 90% of lung cancer cases are the result of smoking. According to the Centers for Disease Control and Prevention (CDC), cigarette smokers are 15–30 times more likely to get lung cancer than nonsmokers.

While not all smokers get lung cancer, and not everyone who has lung cancer is a smoker, there's no doubt that smoking is the biggest risk factor.

Plus, you don't have to be a smoker to be affected. Secondhand smoke also increases your risk of lung cancer. Every year in the United States, about 7,300 people who've never smoked die from lung cancer resulting from secondhand smoke.

Former smokers are still at risk of developing lung cancer, but quitting can lower that risk considerably. Within 10 years of quitting smoking, your chance of dying from lung cancer drops by half.

SCLC is almost always associated with heavy smoking. When you stop smoking, your lungs may be able to heal, reducing your risk of lung cancer.

Radon

Exposure to radon is the second leading cause of lung cancer, according to the American Lung Association.

Your chance of lung cancer also increases by breathing in other hazardous substances such as:

Other risk factors

Other risk factors for lung cancer include:

Genetic mutations: This includes the TP53, EGFR, and KRAS, which can negatively affect cell growth, division, and repair.

A family history of lung cancer: Having family members with lung cancer increases your chance of lung cancer.

A personal history of lung cancer: You're more likely to get lung cancer if you've had lung cancer in the past, especially if you're a smoker.

Previous radiation therapy to the chest: Radiation therapy can increase your risk of lung cancer.

Lung cancer can lead to complications. These include:

High risk of infection: People with lung cancer have a higher chance of pneumonia, bronchitis, and other infections.

Paraneoplastic syndromes: These are conditions resulting from the immune system overreacting to the tumor. These can cause hypercalcemia (increased calcium in your blood), for example. This can also cause various types of brain inflammation.

Facial swelling: Tumors in your lungs can restrict blood flow to your upper body and result in facial swelling.

Loss of lung function: Shortness of breath, difficulty breathing, and other symptoms of reduced lung function can occur in lung cancer patients.

Blood clots: People with lung cancer are at a higher risk of clots, especially in their lower legs.

Spitting up blood: Irritation in airways or from tumors can result in spitting up blood.

Spinal compression: Tumors can press on the spine and cause pain, weakness, and trouble walking.

Heart blockage: Tumors in your lungs can compress heart vessels and lead to multiple serious heart conditions.

Nerve pain: Tumors can result in nerve pain along with numbness, tingling, and weakness.

Trouble swallowing: Lung cancer can spread to your esophagus and cause trouble swallowing.

Neutropenia: This is when your blood doesn't have enough neutrophils, a type of white blood cell that helps protect you from infection.

Kidney dysfunction: This can happen as a result of certain medications.

There is no guaranteed way to prevent lung cancer. However, you can reduce your risk if you:

Quit smoking: Smoking is the number-one risk factor for lung cancer. Eliminating smoking greatly reduces your chance of developing lung cancer.

Avoid radon: You can have your home tested for radon to help reduce your exposure and lung cancer risk.

Avoid other cancer-causing chemicals: Limiting your exposure to other cancer-causing chemicals can reduce your risk.

Eat a healthy diet: There is some evidence to suggest that eating a diet high in fruits and vegetables can reduce your chance of lung cancer.

Lung cancer is most treatable when you catch it early. Unfortunately, the early stages of lung cancer don't always cause symptoms.

Your outlook depends on the type and stage of your cancer, as well as factors such as your age at diagnosis, overall health, and how well your cancer responds to treatment.

As a rule, the earlier your cancer is diagnosed, the better it will respond to treatment.

In recent years, new treatments have gained approval for stage 4 NSCLC. Some people are surviving much longer than previously seen with traditional treatments.

Treatments for lung cancer can be tricky. Options such as chemotherapy, surgery, radiation therapy, and targeted therapy all come with potential side effects that are hard to manage. Additionally, the stigma of having lung cancer often causes self-blame, mental health issues, and reduced quality of life.

To boost your ability to cope with these issues, it's important to use strategies like quitting smoking, eating a healthy diet, and seeking out support networks. Don't be afraid to ask your care team about anything you don't understand — it's perfectly reasonable to get a second opinion at any point during your journey.

It's also beneficial to lean on family and friends for assistance with things like cleaning the house, running errands, taking you to appointments, and just engaging in enjoyable activities not related to cancer. You may find that connecting with patient advocacy groups or learning how to advocate for yourself helps ease some of the difficulties associated with managing your care.

Participating in mind-body therapies or hobbies may reduce stress and increase overall well-being. Moreover, if you are experiencing anxiety or depression, then it may help to reach out to your doctor for counseling or medication.

The ALA provides resources for finding support groups and other helpful advice.

Lung cancer begins in your lungs and can spread to other parts of the body. Your prognosis and treatment will depend on the type of cancer you have and the stage you're diagnosed with.

Treatment often includes surgery, chemotherapy, and radiation. Newer treatments are helping increase survival odds for lung cancer patients, and participating in a clinical trial could offer promise when other treatments stall.

There is no guaranteed way to prevent lung cancer, but by quitting smoking and avoiding hazardous exposures, you can dramatically reduce your chance of developing lung cancer.

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