Trained ILC3 responses promote intestinal defense - Science Magazine

Submission history

Received: 18 October 2019

Accepted: 27 January 2022

Published in print: 25 February 2022

Acknowledgments

We thank all the members of the Di Santo laboratory for critical review of the manuscript, helpful discussions, and support. We thank G. Eberl (Institut Pasteur, France) and O. Mandelboim (Hebrew University, Israel) for providing RorcGFP and Ncr1GFP mice, respectively. We are indebted to S. Novault (Technology Core of the Center for Translational Science at Institut Pasteur, France) for cell sorting and M. Berard, R. Chennouf (Institut Pasteur, France, animal facilities), and M. Lecuit (Institut Pasteur, France) for support. We thank P. Bousso (Institut Pasteur, France) for critical comments on the manuscript.

Funding: This work is supported by grants from the Institut National de la Santé et de la Recherche Médicale (INSERM), the Institut Pasteur, the Agence National pour le Recherche (ANR - ILC_MEMORY), and the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (695467 – ILC_REACTIVITY). A.J. is supported by the French Ministry of Higher Education, Research, and Innovation and by the Fondation pour la recherche médicale.

Author contributions: N.S. and J.P.D. designed the study and wrote the manuscript. N.S. and A.J. designed, performed, and analyzed the experiments. O.D. assisted with the Listeria experiments. P.G. analyzed the microbiota. N.S., O.S., H.V., R.L., and J.-Y.C. performed RNA-seq analysis. L.S. provided metabolism expertise. G.F. provided microbiology expertise. J.P.D. directed the study.

Competing interests: The authors declare no competing financial interests.

Data and materials availability: All data are available in the main text, supplementary materials, or public data repositories [16S rRNA at the NCBI Sequence Read Archive (SUB10763153/BioProject ID: PRJNA786093; RNA-seq datasets: GSE191167)].

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