Poliomyelitis - World Health Organization

Poliomyelitis - World Health Organization

Poliomyelitis - World Health Organization

Posted: 07 Nov 2020 05:10 AM PST

IPV is produced from wild-type poliovirus strains of each serotype that have been inactivated (killed) with formalin. As an injectable vaccine, it can be administered alone or in combination with other vaccines (e.g., diphtheria, tetanus, pertussis, hepatitis B, and haemophilus influenza). Generally three spaced doses are administered to generate adequate levels of seroconversion, and most countries, a booster dose is added during late childhood. IPV has been used successfully in the polio eradication programs in a few countries, notably in Scandinavia and the Netherlands, but until recently most countries have used the oral polio vaccine. IPV provides serum immunity to all three types of poliovirus, resulting in protection against paralytic poliomyelitis. Most studies indicate that the degree of mucosal immunity in the intestine is significantly less than that provided by OPV, although this difference may be less pronounced in the pharyngeal mucosal lining. Adverse events following administration of IPV are very mild and transient. Due to the risks associated with the large quantities of poliovirus needed for IPV production, following the global cessation of poliovirus transmission high level (BSL-3/polio) containment of all manufacturing and quality control areas where live virus is handled must be implemented.

Comments

Post a Comment

Popular posts from this blog

Roseola vs. measles rash: What is the difference? - Medical News Today

Image
Roseola and measles are two different diseases that present with a high fever and a rash. They are both most commonly seen in childhood, although measles can affect people of any age, and roseola in adults is very rare. While both diseases share similarities, there are distinguishing factors, such as how the symptoms present and the disease progression. Read on to find out the difference between roseola and measles rashes. Roseola, also known as roseola infantum, sixth disease, or exanthema subitum, is a viral infection that typically affects children. The human herpesvirus 6 (HHV-6) or human herpesvirus 7 (HHV-7) causes roseola. The disease is spread through tiny respiratory droplets that people either breathe in or pick up from surfaces they touch. This disease usually presents in children between the ages of 6–12 months . Children who have this disease experience a high fever, followed by a pink or red rash. Roseola is a self-limiting viral illness, meaning it will typically go awa...
Read more

poliomyelitis treatment

Image
poliomyelitis treatment Drug and Device News March 2019 - P&T Community Posted: 04 Mar 2019 10:35 AM PST NEW DRUG APPROVALS Ontruzant, a Herceptin Biosimilar The FDA has approved trastuzumabdttb (Ontruzant, Samsung Bioepis Company, Ltd.) for HER2-overexpressing breast cancer and HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma. Trastuzumabdttb, a HER2/neu receptor antagonist, is the third FDA-approved biosimilar of Herceptin (Genentech). Patients should be selected for therapy based on an FDA-approved companion diagnostic. Trastuzumab-dttb carries a boxed warning about the risks of cardiomyopathy, serious and fatal infusion reactions, embryo-fetal toxicity, and pulmonary toxicity. Ontruzant will be marketed and distributed in the U.S. by Merck. Sources: Samsung Bioepis, January 21, 2019; Ontruzant . prescribing information, January 2019; FDA, January 18, 2019 Vaxelis, a Combination Vaccine T...
Read more

Coronavirus fake news echoes century-old polio fears - Newsroom

Image
Coronavirus fake news echoes century-old polio fears - Newsroom Coronavirus fake news echoes century-old polio fears - Newsroom Posted: 05 Feb 2020 08:32 AM PST FEBRUARY 6, 2020 Updated 15 hours ago Dr Heather Battles Dr Heather Battles is a lecturer in anthropology at the University of Auckland and researches infectious diseases and epidemics. Show more Ideasroom During the past month, in the confusion and uncertainty over the precise origin of the 2019 novel coronavirus outbreak, many alternate ideas or 'conspiracy theories' have sprung up and spread widely via social media including Twitter and Facebook. I have had a sense of déjà vu as many of these claims have parallels in how people responded to another 'emerging' epidemic disease a century ago: polio. The first example that struck me is the idea (spread by US fake news website Infowars and others) that the roll-out of 5G technology is to blame, wit...
Read more