Perspectives on the diagnosis & management of onychomycosis | CCID - Dove Medical Press
Introduction Onychomycosis is a fungal infection of the nail unit caused by dermatophytes, non-dermatophyte molds (NDM) and yeast. 1,2 It is the most common nail infection encountered in clinical practice, 3 with a worldwide prevalence of 5.5%, and an estimated prevalence of 2% to 14% in the United States (US), 4 and 0.5% to 24% in Europe. 5–8 Risk factors include prior dermatologic conditions, such as hyperhidrosis, tinea pedis, and psoriasis, as well as exogenous factors, including occlusive shoes, trauma, and poor nail grooming. Comorbidities, such as diabetes mellitus, immunosuppression, malignancy, venous insufficiency, peripheral arterial disease, obesity, and inflammatory bowel disease also increase risk. 4 Altered foot biomechanics due to biomechanical malignments, congenital deformities, or neurological deficits can result in repetitive microtrauma during walking and increase the risk of infection and recurrence. 9,10 Genetics may predispose to developing infection 1...