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Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice - Science

[unable to retrieve full-text content] Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice    Science

Bacterial Arthritis: Causes, Symptoms, and Treatment - Verywell Health

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Bacterial arthritis—also called septic arthritis and infectious arthritis—is a rare and sometimes serious infection of one or more joints. It occurs when an infection spreads to a joint and causes inflammation of the joint and surrounding tissues. The terms "septic arthritis" and "infectious arthritis" refer to infections from all sources, such as bacteria, viruses, and fungi. In contrast, "bacterial arthritis" refers to bacteria as the source of infectious or septic arthritis. With bacterial arthritis, the inflammation occurs at the surface of the cartilage lining the joints and the synovial fluid responsible for lubricating the joints. Bacteria can cause an infection elsewhere in the body that spreads through the bloodstream and infects a joint. The article will cover the symptoms and causes of bacterial arthritis and how it is diagnosed and treated. m-gucci / Getty Images Bacterial Arthritis Symptoms The ...

GSK raises profit guidance after strong sales of shingles vaccine - Financial Times

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GSK has raised its full-year revenue and profit guidance after soaring sales of its shingles vaccine helped the UK drugmaker beat expectations in the second quarter of the year. The pharmaceutical company expects sales to grow 6-8 per cent in 2022, up from its previous forecast of 5-7 per cent. The new guidance for adjusted operating profit growth is 13-15 per cent, above its previous forecast of 12-14 per cent. The results are the first since GSK spun off its consumer health division Haleon this month. Emma Walmsley, GSK chief executive, said the company was strengthening its pipeline of future drugs, pointing to a recent positive trial result for its vaccine candidate for the respiratory syncytial virus. "This is GSK's first set of results as a newly focused biopharma company, and we have delivered an excellent second-quarter performance, with strong growth in speciality medicines, including HIV, and a record quarter for our shingles vaccine Shingrix," she sai...

China has helped spread four epidemics — and COVID’s not the last - New York Post

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For more than two years we have lived through a pandemic that no one — no one who doesn't fall for Communist Chinese propaganda anyway — doubts came from China.   In fact, the consensus now is that COVID came from the Wuhan lab, something I wrote about in these pages at the outset of the outbreak. In recent months, many of those who had earlier parroted Beijing's line about COVID coming from a bat cave, including China's man at the World Health Organization, Dr. Tedros Ghebreyesus, have come over to my point of view. At the same time, there is mounting evidence that the coronavirus was developed as part of China's bioweapons program. But, leaving all this aside, there is no doubt on one key point. The Chinese Communist Party has a long history of covering up epidemics within China, and then carelessly — or deliberately — allowing...

Chronic Stress: Symptoms, Examples, Effects, and Treatment - Verywell Health

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Everyone experiences stress from time to time. Often, stress is acute (short-term) and goes away quickly. When stress persists and becomes ongoing, it is known as chronic stress. In the short term, stress can be beneficial. It helps you avoid danger, handle immediate situations, and build resiliency. However, if stress becomes prolonged, occurs too often, or isn't managed well, it can have negative health effects. Read on to learn more about chronic stress and how it can be managed. Luis Alvarez / Getty Images What Is Chronic Stress? The body has a built-in system for handling stress called the stress response (also known as the "fight or flight" response). When an acute stressor presents, the body reacts through a variety of brain and body reactions, such as the release of adrenaline ( epinephrine ) and cortisol , that prepares us to deal with the potential threat. The response is meant to be momentary, and the body attem...

Polio in New York: Is an outbreak in the U.S. likely? - Medical News Today

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Share on Pinterest Polio can effectively be prevented with vaccines. Catherine Falls Commercial/Getty Images Polio is a viral disease that can cause paralysis and even death. However, thanks to effective and widespread vaccination, poliovirus disease has been largely eradicated. A recent case of polio identified in New York, the United States—the first in almost ten years—has caused concern among the public. Experts believe that the likelihood of spread is very low and the isolated case likely came from a person who developed polio after being exposed to someone who had received a live vaccine. Polio is a viral disease that can have a severe impact, leading to paralysis and death in some cases. Since the first polio vaccine became available in 1955, the impact of polio has diminished. Cases are now rare in the U.S. and much of the world. However, the Associated Press recently reported a case of polio identified in Rockland County, New York, marking the first case in almost a decade. Ba...

Prevalence of significant bacterial nosocomial infection | IDR - Dove Medical Press

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Introduction Antibiotic resistance is becoming a global issue every year, with estimated 2.8 million people in the United States developing antibiotic-resistant diseases. Higher rates of morbidity, mortality, and healthcare costs are linked to certain infections. Drug-resistant Gram-negative bacteria, on the other hand, are becoming more common in the United States and around the world. In the past, Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus and Clostridium difficile were the most concerning in terms of antibiotic resistance. 1 Beta-lactam antimicrobial drugs are the most commonly prescribed antibiotics for bacterial infections, and they continue to be a major source of Gram-negative bacteria resistance globally. Bacterial strains exposed to a variety of Beta-lactam antibiotics have acquired an energetic and constant production and mutation of Beta-lactames, increasing their activity even against recently produced Beta-lactam antibiotics. 2 In ...