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Showing posts from January, 2025

Evolution of pulmonary hypertension in interstitial lung disease: a journey through past, present, and future

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hps disease :: Article Creator

Clinical significance of pulmonary hypertension in interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's innovative drug development initiative—Group 3 pulmonary hypertension

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left ventricular failure causes :: Article Creator What's The Difference Between Left- And Right-Sided Heart Failure? FG Trade Latin / Getty Images Heart failure occurs when the heart can't pump blood as well as it should. It can affect either the left side of the heart (left-sided heart failure) or the right side (right-sided heart failure). Heart failure can cause a variety of symptoms depending on which side is affected. In left-sided heart failure, the left side of the heart cannot efficiently pump blood to the body. This can lead to a backup of blood in the lungs and symptoms like coughing and tiredness. Right-sided heart failure happens when the right side of the heart can't adequately pump blood to the lungs to pick up oxygen. This can cause blood to back up in the veins and cause symptoms like swelling and nausea. Left-sided heart failure usually occurs first. Right-sided heart failure is typically a result of l...

State-of-the-art evidence in the treatment of systemic sclerosis

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pulmonary artery stenosis surgery :: Article Creator

Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure | Circulation

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pheochromocytoma hypertension :: Article Creator FDA Grants Priority Review To Merck's Welireg For Advanced, Unresectable, Or Metastatic Pheochromocytoma, Paraganglioma Priority review for Welireg is based on data from the Phase II LITESPARK-015 trial, which showed promising response rates in patients with advanced, unresectable, or metastatic pheochromocytoma and paraganglioma. Image Credit: Adobe Stock Images/Dr_Microbe The FDA has granted Priority Review to Merck's supplemental new drug application (sNDA) for Welireg (belzutifan), an oral HIF-2α inhibitor, for treating adult and pediatric patients over 12 years of age with advanced, unresectable, or metastatic pheochromocytoma and paraganglioma (PPGL). According to the company, the sNDA is supported by findings from the Phase II LITESPARK-015 trial, which demonstrated a promising objective response rate (ORR) and duration of response (DOR). Currently, there are no approved t...

Group 3 Pulmonary Hypertension: From Bench to Bedside

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heart embolism :: Article Creator Flossing Just Once A Week May Lower Stroke Risk Flossing your teeth at least once a week may reduce your risk of stroke and irregular heartbeat, according to a preliminary study to be presented next week at the American Stroke Association's International Stroke Conference 2025 in Los Angeles. [1] "Flossing was also linked to better overall health, including lower blood pressure, healthier cholesterol levels, and lower chances of diabetes," says study lead author Souvik Sen, MD, chair of the neurology department at the University of South Carolina School of Medicine and a neurologist at Prisma Health in Columbia, South Carolina. Exploring the Link Between Oral and Heart Health The researchers were looking to find out which oral hygiene behavior — dental flossing, brushing, or regular dentist visits — had the greatest impact on stroke prevention. The study included about 6,300 people. About 65 ...

Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure | Circulation

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severe tr pah :: Article Creator

Evolution of pulmonary hypertension in interstitial lung disease: a journey through past, present, and future

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cardiac failure symptoms :: Article Creator Could Flu, COVID, RSV Symptoms Actually Be A Heart Attack? STATEN ISLAND, N.Y. — During the recent surge in influenza, COVID-19, norovirus, respiratory syncytial virus (RSV) and other respiratory viruses, it's critical to pay close attention to your heart and symptoms, cardiology experts warn. "Some patients may think that symptoms such as being short of breath, weak, cold, or feverish, or having dizziness or chest pain may be solely a result of these winter viruses, but these symptoms could also be associated with, and masking, dangerous cardiovascular complications, such as heart attack, pulmonary embolism, viral myocarditis, pericarditis, or even heart failure,'' an announcement from Mount Sinai Fuster Heart Hospital stated. Some patients have been missing serious heart complication symptoms, thinking they have the flu, the doctors warned. "For example, some patient...

State-of-the-art evidence in the treatment of systemic sclerosis

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coastal pulmonary :: Article Creator

Clinical significance of pulmonary hypertension in interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's innovative drug development initiative—Group 3 pulmonary hypertension

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tacrolimus pulmonary hypertension :: Article Creator

Group 3 Pulmonary Hypertension: From Bench to Bedside

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chronic heart failure treatment :: Article Creator Lilly Cuts Mid-stage Relaxin Study In Chronic Kidney Disease For 'Lack Of Foreseeable Clinical Benefit' Eli Lilly last week terminated a Phase II trial of its investigational relaxin analog volenrelaxin in chronic kidney disease, according to an update to the study's clinicaltrials.Gov webpage. Lilly is dropping the study because of "a lack of foreseeable clinical benefit" in its target chronic kidney disease (CKD) population. The termination notice also referenced a similarly discontinued "related heart failure study that demonstrated no benefit in an overlapping patient group." It remains unclear what cardiovascular study this is, though another Phase II trial of the candidate in chronic heart failure with preserved ejection fraction remains tagged as active but is not recruiting. BioSpace has reached out to Eli Lilly for clarification and will update this space...

Hypoxia Inducible Factors as Central Players in the Pathogenesis and Pathophysiology of Cardiovascular Diseases

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lung damage from cardiac arrest :: Article Creator What Is Cardiac Arrest? Why Is It So Deadly? Just a moment... This request seems a bit unusual, so we need to confirm that you're human. Please press and hold the button until it turns completely green. Thank you for your cooperation! Press and Hold Press and hold the button If you believe this is an error, please contact our support team. 167.71.87.121 : 7379718f-dd75-4143-b1a7-902bbc79

The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease

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pah pathophysiology :: Article Creator

Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approach

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hypoxic pulmonary hypertension :: Article Creator IPF: Death Knell For The Lungs? From common cold, flu, high blood pressure, blood clots in the lungs, lung cancer to as severe as Idiopathic pulmonary fibrosis (IPF) disease that claimed the late tabla maestro Ustad Zakir Hussain's life, all are currently in focus. Reputed pulmonologists Dr. D.P. Bansal and Dr. Sulaiman Ladhani weigh in. Breathe easy and healthy. That is what doctors recommend for eight to 80. But inhaling fresh air from clean surroundings seems scarce nowadays. With the surge in SPM count (suspended particulate matter) and a blanket of smog covering every urban space this winter, human lungs are being badly hit. Even the demand for air-purifiers in most homes this season is noticing a huge spike. As a result, lung diseases and associated complications are on the rise. The current talking point is IPF or the chronic idiopathic pulmonary fibrosis ailment that caused ace internat...

(PDF) Pathophysiology and new advances in pulmonary hypertension

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pulmonary cancer :: Article Creator The Early Lung Cancer Warning Symptom You Can Feel In Your Fingers And Toes You may not notice any obvious signs of lung cancer in its early stages, but they may show up in some unexpected parts of your body as it progresses Feeling pins and needles may be a sign of something serious, experts say ( Image: E+/Getty Images) Lung cancer, one of the four most common types of cancer in the UK, sees over 49,000 new cases each year, according to Cancer Research UK. This disease is triggered by an uncontrolled growth of abnormal cells in one or both lungs, which are crucial for oxygen intake and carbon dioxide expulsion. Lung cancer in its early stages may not exhibit any noticeable symptoms. However, as the disease progresses, symptoms can appear throughout the body. In rare instances, people might experience pins and needles or numbness in their fingers or toes if lung cancer cells release hormones...