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Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association

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left ventricular diastolic dysfunction treatment :: Article Creator Impact Of Azelnidipine Treatment On Left Ventricular Diastolic Performance In Patients With Hypertension And Mild Diastolic Dysfunction: Multi-center Study With Echocardiography Ho KK, Pinsky JL, Kannel WB, Levy D . The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol 1993; 22 (Suppl A): 6A–13A. Article  CAS  Google Scholar  Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK . The progression from hypertension to congestive heart failure. JAMA 1996; 275: 1557–1562. Article  CAS  Google Scholar  Redfield MM, Jacobsen SJ, Burnett Jr JC, Mahoney DW, Bailey KR, Rodeheffer RJ . Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003; 289: 194–202. Article  Google Scholar  Aurigemma GP . Diastolic heart failure—a common and lethal condition by any name. N Engl J Med ...

Edema formation in congestive heart failure and the underlying mechanisms

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severe hypertension :: Article Creator Silent Warning Signs Your Blood Pressure May Be Dangerous These overlooked symptoms could signal a serious health emergency requiring immediate attention High blood pressure affects nearly half of all adults, yet many remain completely unaware their numbers have reached dangerous territory. This silent condition rarely announces itself with obvious symptoms, earning its notorious reputation as the "silent killer" among medical professionals and health advocates alike. The challenge with elevated blood pressure lies in its deceptive nature. Unlike a broken bone or severe infection, dangerously high blood pressure can quietly damage your organs for months or even years before producing any noticeable signs. By the time symptoms finally appear, significant damage may have already occurred to your heart, kidneys, brain, or blood vessels. Understanding the subtle warning signs your body may be sendin...

Bosentan Therapy for Pulmonary Arterial Hypertension

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lung abscess diagnosis :: Article Creator Abscess In The Chest: What To Know A chest abscess tends to refer to an abscess in the lungs. This also includes abscesses in the muscles of the chest wall, between the lung tissue and the lining of the chest cavity. An abscess is a painful collection of pus. Abscesses can occur almost anywhere in the body, for example, the skin or mouth. Treatment typically involves antibiotics and draining them. Left untreated, chest abscesses can cause serious health conditions. This article will explain what a chest abscess is, what causes it, and the typical symptoms. It will also look at diagnosis, treatment, and possible complications. The location of the abscess in the body can determine what symptoms a person might experience. Some people with a lung abscess will have no symptoms at all. Others may experience: Abscesses can develop when bacteria, viruse...

Classification and pathophysiology of pulmonary hypertension - Sysol - 2018 - Continuing Cardiology Education

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main cause of pulmonary hypertension :: Article Creator Sotatercept Demonstrates Major Risk Reduction In Advanced PAH: ZENITH Trial Sotatercept significantly reduced the risk of all-cause mortality, lung transplantation, or ≥24-hour hospitalization for worsening pulmonary arterial hypertension by 76% in high-risk patients on maximally tolerated background therapy, a new study has reported. In a pivotal advance for patients with pulmonary arterial hypertension (PAH) at high risk of death, the ZENITH phase 3 trial has demonstrated that add-on sotatercept therapy significantly reduces major clinical events including death,lung transplantation, and PAH-related hospitalization. Published in the New England Journal of Medicine (May 2025 issue), the trial provides compelling evidence for the use of sotatercept as a disease-modifying agent in a population with WHO functional class III or IV PAH and a REVEAL Lite 2 risk score ≥9. In this double-b...

Evaluation and Management of Pulmonary Hypertension in Noncardiac Surgery: A Scientific Statement From the American Heart Association | Circulation

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pulmonary hypertension portal hypertension :: Article Creator Portal Hypertension Symptoms & Their Most Common Complications Portal Hypertension Symptoms and Their ComplicationsPortal hypertension is a condition in which increased pressure within the portal vein—an important vessel that carries blood from the stomach and intestines to the liver—rises beyond normal levels. This rise in pressure often occurs due to advanced liver disease, particularly cirrhosis. Cirrhosis causes the liver to develop scars that replace healthy liver tissue, which makes it difficult for blood to flow freely through the organ. When that primary route of blood flow becomes blocked or narrowed, pressure in the portal vein begins to climb, forcing blood to divert into smaller blood vessels. Over time, these smaller vessels can swell under the added load, eventually leading to various complications [1]. Table of Contents Causes of Portal Hypertension Portal hypertension c...

Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure | Circulation

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hepatic congestion heart failure :: Article Creator What To Know About Cardiac Cirrhosis Cardiac cirrhosis is a serious liver disorder that can be triggered by cardiac (heart) circulation issues such as heart failure. The key to managing it is to effectively treat the underlying heart condition. The term "cardiac cirrhosis" refers to any of the liver disorders that can develop when heart problems lead to congestion or fluid buildup in your liver. Your liver relies on healthy circulation to function properly. When a heart condition reduces blood flow, serious liver problems can occur. Treating cardiac cirrhosis involves managing the heart problem at the root of the liver disorder. If you have cardiac cirrhosis, your outlook will depend largely on the health and status of your heart. This article takes a closer look at the symptoms, causes, diagnosis, and treatment of cardiac cirrhosis. Heart health and li...